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T-2-四醇

T-2-四醇用途

T-2 Tetraol 是一种单端孢真菌毒素,毒性小,不能诱导凋亡。

T-2-四醇名称

[ CAS 号 ]:
34114-99-3

[ 中文名 ]:
T-2 四醇 T-2 毒素代谢物

[ 英文名 ]:
T-2 Tetraol

[英文别名 ]:

T-4 toxin
t-2toxintetraol
t-2tetraol

T-2-四醇生物活性

[ 描述 ]:

T-2 Tetraol 是一种单端孢真菌毒素,毒性小,不能诱导凋亡。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Engler KH, et al. A colorimetric technique for detecting trichothecenes and assessing relative potencies. Appl Environ Microbiol. 1999 May;65(5):1854-7.

[2]. Islam Z, et al. Structure-function relationship of T-2 toxin and its metabolites in inducing thymic apoptosis in vivo in mice. Biosci Biotechnol Biochem. 1998 Aug;62(8):1492-7.

T-2-四醇物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
515.2±50.0 °C at 760 mmHg

[ 熔点 ]:
125°C- 135 °C

[ 分子式 ]:
C₁₅H₂₂O₆

[ 分子量 ]:
298.332

[ 闪点 ]:
265.4±30.1 °C

[ 精确质量 ]:
298.141632

[ PSA ]:
102.68000

[ LogP ]:
-0.77

[ 蒸汽压 ]:
0.0±3.0 mmHg at 25°C

[ 折射率 ]:
1.644

[ 储存条件 ]:
−20°C

T-2-四醇MSDS

T-2-四醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YC9980000

CHEMICAL NAME :: Trichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol, 12,13-epoxy-

CAS REGISTRY NUMBER :: 34114-99-3

LAST UPDATED :: 198910

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C14-H22-O6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 4,135,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 26,923,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 184 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - fluid intake Behavioral - ataxia

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 26,923,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 24,985,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 24,985,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 4,135,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 4,135,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 25,335,1983

T-2-四醇安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302 + H312 + H332-H319

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
26/27/28-36/37/38

[ 安全声明 (欧洲) ]:
22-36/37/39-45

[ 危险品运输编码 ]:
UN2811 6.1/PG 1

[ RTECS号 ]:
YC9980000

T-2-四醇合成路线

T-2-四醇上下游产品

T-2-四醇上游产品

T-2-四醇下游产品

T-2-四醇文献

Occurrence and distribution of 13 trichothecene toxins in naturally contaminated maize plants in Germany.

Toxins (Basel.) 4(10) , 778-87, (2012)

The objective of the present study was to monitor the occurrence and distribution of a spectrum of trichothecene toxins in different parts of maize plants. Therefore maize plants were sampled randomly...

The natural occurrence of T-2 toxin and fumonisins in maize samples in Croatia.

Bull. Environ. Contam. Toxicol. 88(6) , 863-6, (2012)

Maize (Zea mays) considered to be one of the most frequent crops in Croatia, is often contaminated with Fusarium mycotoxins. The aim of this study was to investigate the possible contamination of maiz...

Production of T-2 toxin and related trichothecenes on different media.

Acta Vet. Hung. 32(3-4) , 147-52, (1984)

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