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博来霉素

博来霉素用途

硼霉素是从抗生素链霉菌[1]中分离的化合物。

博来霉素名称

[ CAS 号 ]:
34524-20-4

[ 中文名 ]:
博来霉素

[ 英文名 ]:
Boromycin

[英文别名 ]:

Boromycin

博来霉素生物活性

[ 描述 ]:

硼霉素是从抗生素链霉菌[1]中分离的化合物。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Surup F, et al. Activation of the NLRP3 Inflammasome by Hyaboron, a New Asymmetric Boron-Containing Macrodiolide from the Myxobacterium Hyalangium minutum. ACS Chem Biol. 2018;13(10):2981-2988.

博来霉素物理化学性质

[ 分子式 ]:
C₄₅H₇₃BNO₁₅

[ 分子量 ]:
878.87000

[ 精确质量 ]:
878.50700

[ PSA ]:
209.99000

[ LogP ]:
5.59010

[ 储存条件 ]:
-20°C，避光干燥

博来霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ED7325000

CHEMICAL NAME :: Boromycin

CAS REGISTRY NUMBER :: 34524-20-4

LAST UPDATED :: 199206

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C45-H74-B-N-O15

MOLECULAR WEIGHT :: 880.01

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 50,1533,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HINAAU Hindustan Antibiotics Bulletin. (Hindustan Antibiotics, Ltd., Pimpri, Poona, India) V.1- 1958- Volume(issue)/page/year: 11,26,1969