美西麦角
美西麦角名称
[ CAS 号 ]:
361-37-5
[ 中文名 ]:
美西麦角
[ 英文名 ]:
methysergide
[英文别名 ]:
- Metisergide
- Desernil
- Deseril
- Methysergid
- Sansert
- Metisergide [DCIT]
- Desernyl
- Deseryl
- methsergide
- Methysergidum
美西麦角物理化学性质
[ 密度 ]:
1.28g/cm3
[ 沸点 ]:
634.4ºC at 760mmHg
[ 分子式 ]:
C21H27N3O2
[ 分子量 ]:
353.45800
[ 闪点 ]:
337.5ºC
[ 精确质量 ]:
353.21000
[ PSA ]:
57.50000
[ LogP ]:
2.26390
[ 折射率 ]:
1.658
美西麦角毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KE5300000
- CHEMICAL NAME :
- Ergoline-8-beta-carboxamide, 9,10-didehydro-N-(1-(hydroxymethyl)propyl)-1,6-dimeth yl-
- CAS REGISTRY NUMBER :
- 361-37-5
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C21-H27-N3-O2
- MOLECULAR WEIGHT :
- 353.51
- WISWESSER LINE NOTATION :
- T C6656 1A P GN LN CUTT&&J EVMY2&1Q G1 L1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 28 ug/kg
- TOXIC EFFECTS :
- Behavioral - anorexia (human) Behavioral - headache Gastrointestinal - nausea or vomiting
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 16,220,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 440 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 185 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963
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