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3'-去磷酸辅酶 A

3'-去磷酸辅酶 A用途

去磷酸辅酶A是辅酶A(CoA)的直接前体。去磷酸辅酶A激酶(DPCK)催化去磷酸辅酶CoA的ATP依赖性磷酸化,这是辅酶A(CoA)生物合成的最后一步[1][2]。

3'-去磷酸辅酶 A名称

[ CAS 号 ]:
3633-59-8

[ 中文名 ]:
3′-脱磷酸辅酶A

[ 英文名 ]:
3'-O-dephosphono-coenzyme A

[英文别名 ]:

3′-Dephosphocoenzyme A
3'-DEPHOSPHOCOENZYME A

3'-去磷酸辅酶 A生物活性

[ 描述 ]:

去磷酸辅酶A是辅酶A(CoA)的直接前体。去磷酸辅酶A激酶(DPCK)催化去磷酸辅酶CoA的ATP依赖性磷酸化,这是辅酶A(CoA)生物合成的最后一步[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Swift RP, et al. Dephospho-CoA kinase, a nuclear-encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption. EMBO J. 2021 Aug 16;40(16):e107247.

[2]. Shimosaka T, et al. Identification of Dephospho-Coenzyme A (Dephospho-CoA) Kinase in Thermococcus kodakarensis and Elucidation of the Entire CoA Biosynthesis Pathway in Archaea. mBio. 2019 Jul 23;10(4):e01146-19.

3'-去磷酸辅酶 A物理化学性质

[ 密度 ]:
1.85±0.1 g/cm3(Predicted)

[ 分子式 ]:
C₂₁H₃₅N₇O₁₃P₂S

[ 分子量 ]:
687.55400

[ 精确质量 ]:
687.14900

[ PSA ]:
358.45000

[ 储存条件 ]:
-20 °C，密封，干燥

3'-去磷酸辅酶 A安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

3'-去磷酸辅酶 A文献

Simultaneous high-performance liquid chromatography determination of coenzyme A, dephospho-coenzyme A, and acetyl-coenzyme A in normal and pantothenic acid-deficient rats.

Anal. Biochem. 430(2) , 151-5, (2012)

We describe here a simultaneous high-performance liquid chromatography method for practical and rapid determination of coenzyme A (CoA), dephospho-CoA, and acetyl-CoA in tissues. These coenzymes are b...

Identification of the active site of phosphoribosyl-dephospho-coenzyme A transferase and relationship of the enzyme to an ancient class of nucleotidyltransferases.

Biochemistry 39(43) , 13233-40, (2000)

Malonate decarboxylase from Klebsiella pneumoniae contains an acyl carrier protein (MdcC) to which a 2'-(5' '-phosphoribosyl)-3'-dephospho-CoA prosthetic group is attached via phosphodiester linkage t...

Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli.

J. Biol. Chem. 274(38) , 27105-11, (1999)

Phosphopantetheine adenylyltransferase (PPAT) catalyzes the penultimate step in coenzyme A (CoA) biosynthesis: the reversible adenylation of 4'-phosphopantetheine yielding 3'-dephospho-CoA and pyropho...

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