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3-甲基-2-氧代丁酸钠

3-甲基-2-氧代丁酸钠用途

3-甲基-2-氧代丁酸钠是大肠杆菌中泛酸的前体[1][2][3]。

3-甲基-2-氧代丁酸钠名称

[ CAS 号 ]:
3715-29-5

[ 中文名 ]:
3-甲基-2-氧代丁酸钠

[ 英文名 ]:
Sodium 3-methyl-2-oxobutanoate

[英文别名 ]:

Butanoic acid, 3-methyl-2-oxo-, sodium salt (1:1)
MFCD00002581
EINECS 223-062-2
sodium,3-methyl-2-oxobutanoate
Butanoic acid, 3-methyl-2-oxo-, sodium salt
Sodium 3-methyl-2-oxobutanoate
3-Methyl-2-oxobutanoic acid

3-甲基-2-氧代丁酸钠生物活性

[ 描述 ]:

3-甲基-2-氧代丁酸钠是大肠杆菌中泛酸的前体[1][2][3]。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

3-甲基-2-氧代丁酸钠(α-酮异戊酸)是大肠杆菌中泛酸的前体[1]。3-甲基-2-氧代丁酸钠(α-酮异戊酸)增强α-酮异己酸和α-酮-β-甲基-n-戊酸,但减少相应的氨基酸,导致鸟氨酸的早期下降以及血浆精氨酸的晚期增加[2]。

[体内研究]

3-甲基-2-氧代丁酸钠(α-酮异戊酸)通过GABA能和谷氨酸能机制诱导大鼠惊厥[3]。

[参考文献]

[1]. MAAS WK, et al. alpha-Ketoisovaleric acid, a precursor of pantothenic acid in Escherichia coli. J Bacteriol. 1953 Apr;65(4):388-93.

[2]. Schauder P, et al. Oral administration of alpha-ketoisovaleric acid or valine in humans: blood kinetics and biochemical effects. J Lab Clin Med. 1984 Apr;103(4):597-605.

[3]. Coitinho AS, et al. Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats. Brain Res. 2001 Mar 9;894(1):68-73.

3-甲基-2-氧代丁酸钠物理化学性质

[ 沸点 ]:
170.2ºC at 760 mmHg

[ 熔点 ]:
220-230 °C (dec.)(lit.)

[ 分子式 ]:
C₅H₇NaO₃

[ 分子量 ]:
138.097

[ 精确质量 ]:
138.029282

[ PSA ]:
57.20000

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
Store at 0-5°C

3-甲基-2-氧代丁酸钠MSDS

3-甲基-2-氧代丁酸钠安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2904909090

3-甲基-2-氧代丁酸钠合成路线

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3-甲基-2-氧代丁酸钠海关

[ 海关编码 ]: 2918300090

[ 中文概述 ]:
2918300090 其他含醛基或酮基不含其他含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

3-甲基-2-氧代丁酸钠文献

Inhibition of brain energy metabolism by the alpha-keto acids accumulating in maple syrup urine disease.

Biochim. Biophys. Acta 1639(3) , 232-8, (2003)

Neurological dysfunction is a common finding in patients with maple syrup urine disease (MSUD). However, the mechanisms underlying the neuropathology of brain damage in this disorder are poorly known....

Amino acid metabolism in the human fetus at term: leucine, valine, and methionine kinetics.

Pediatr. Res. 70(6) , 566-71, (2011)

Human fetal metabolism is largely unexplored. Understanding how a healthy fetus achieves its fast growth rates could eventually play a pivotal role in improving future nutritional strategies for prema...

Direct methods and residue type specific isotope labeling in NMR structure determination and model-driven sequential assignment.

J. Biomol. NMR 42(2) , 111-27, (2008)

Direct methods in NMR based structure determination start from an unassigned ensemble of unconnected gaseous hydrogen atoms. Under favorable conditions they can produce low resolution structures of pr...

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