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4-甲基伞形酮-Α-D-吡喃半乳糖苷

4-甲基伞形酮-Α-D-吡喃半乳糖苷用途

4-甲基伞形花序基-α-D-半乳吡喃糖苷(4MU-α-Gal)是α-半乳糖苷酶a(GLA)的底物,是一种蓝色亲荧光底物。4-甲基伞形花序基-α-D-半乳吡喃糖苷在被GLA切割后形成两种产物,半乳糖和荧光4MU[1]。

4-甲基伞形酮-Α-D-吡喃半乳糖苷名称

[ CAS 号 ]:
38597-12-5

[ 中文名 ]:
4-甲基伞形酮-Alpha-D-吡喃半乳糖苷

[ 英文名 ]:
4-methylumbelliferyl α-D-galactoside

[中文别名 ]:

[英文别名 ]:

4-methylumbelliferyl α-D-galactoside
4-METHYLUMBELLIFERYL-α-D-GALACTOPYRANOSIDE
MFCD00063278
EINECS 254-031-1

4-甲基伞形酮-Α-D-吡喃半乳糖苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

4-甲基伞形花序基-α-D-半乳吡喃糖苷(4MU-α-Gal)的发射波长为440nm,激发波长为365 nm[1]。

[参考文献]

[1]. Omid Motabar, et al. High throughput screening for inhibitors of alpha-galactosidase. Curr Chem Genomics. 2010 Dec 3;4:67-73.

4-甲基伞形酮-Α-D-吡喃半乳糖苷物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
626.9±55.0 °C at 760 mmHg

[ 熔点 ]:
171-173ºC

[ 分子式 ]:
C₁₆H₁₈O₈

[ 分子量 ]:
338.309

[ 闪点 ]:
233.9±25.0 °C

[ 精确质量 ]:
338.100159

[ PSA ]:
129.59000

[ LogP ]:
-0.46

[ 外观性状 ]:
白色至近乎于白色结晶粉末

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.641

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: 10 mg/mL hot, clear, colorless

4-甲基伞形酮-Α-D-吡喃半乳糖苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
R26/27/28

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

4-甲基伞形酮-Α-D-吡喃半乳糖苷合成路线

详细合成路线

4-甲基伞形酮-Α-D-吡喃半乳糖苷上下游产品

4-甲基伞形酮-Α-D-吡喃半乳糖苷上游产品

4-甲基伞形酮-Α-D-吡喃半乳糖苷下游产品

4-甲基伞形酮-Α-D-吡喃半乳糖苷文献

A 45-kDa midgut glycoprotein from Anopheles albimanus mosquito mediates the killing of trypanosomes.

Cell Biochem. Funct. 20(3) , 257-62, (2002)

Trypanosomes do not inhabit or grow in anopheles mosquitoes, the vector for the transmission of Plasmodium parasites the causative agent for malaria. The possession of lytic factors by the anopheline ...

[A combined chromogenic-fluorogenic medium for the simultaneous detection of coliform groups and E. coli in water].

Zentralbl. Hyg. Umweltmed. 189 , 225, (1989)

A comparison was made with different chromogenic and fluorogenic substrates, 4-methylumbelliferyl-beta-D-glucuronide (MUG), 4-nitrophenyl-beta-D-glucuronide (PNPG), 4-methylumbelliferyl-beta-D-galacto...

The chaperone activity and toxicity of ambroxol on Gaucher cells and normal mice.

Brain Dev. 35(4) , 317-22, (2013)

Gaucher disease (GD), caused by a defect of acid β-glucosidase (β-Glu), is one of the most common sphingolipidoses. Recently, ambroxol, an FDA-approved drug used to treat airway mucus hypersecretion a...

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