盐酸吲哚拉明

盐酸吲哚拉明用途

吲哚拉明(盐酸盐)是一种新型降血压药。?吲哚拉明(盐酸盐)对?α1A-肾上腺素受体也具有选择性。

盐酸吲哚拉明名称

[ CAS 号 ]:
38821-52-2

[ 中文名 ]:
盐酸吲哚拉明

[ 英文名 ]:
N-(1-(2-(1H-INDOL-3-YL)ETHYL)PIPERIDIN-4-YL)BENZAMIDE HYDROCHLORIDE

[英文别名 ]:

Indoramin hydrochloride

盐酸吲哚拉明生物活性

[ 描述 ]:

吲哚拉明(盐酸盐)是一种新型降血压药。?吲哚拉明(盐酸盐)对?α1A-肾上腺素受体也具有选择性。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. R B Royds, et al. The effect of indoramin on peripheral blood flow. Br J Clin Pharmacol. 1974, 13, 7.

盐酸吲哚拉明物理化学性质

[ 沸点 ]:
600ºC at 760mmHg

[ 分子式 ]:
C₂₂H₂₆ClN₃O

[ 分子量 ]:
383.91

[ 闪点 ]:
316.7ºC

[ 精确质量 ]:
383.176453

[ PSA ]:
51.62000

[ LogP ]:
4.91950

盐酸吲哚拉明MSDS

详细MSDS(安全技术说明书)

盐酸吲哚拉明毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV5396000

CHEMICAL NAME :: Benzamide, N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 38821-52-2

LAST UPDATED :: 199707

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C22-H25-N3-O.Cl-H

MOLECULAR WEIGHT :: 383.96

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 7 mg/kg/1W-I

TOXIC EFFECTS :: Behavioral - wakefulness Behavioral - excitement Cardiac - pulse rate increase, without fall in BP

REFERENCE :: PRACAK Practitioner. (Morgan-Grampian Ltd., 40 Beresford St., Woolwich, London SE18 6BQ, UK) V.1- 1868- Volume(issue)/page/year: 228,362,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 43NDAD "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New York, Raven Press, 1980 Volume(issue)/page/year: -,161,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 43NDAD "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New York, Raven Press, 1980 Volume(issue)/page/year: -,161,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 43NDAD "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New York, Raven Press, 1980 Volume(issue)/page/year: -,161,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 43NDAD "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New York, Raven Press, 1980 Volume(issue)/page/year: -,161,1980

盐酸吲哚拉明安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
22-36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
CV5396000

[ 海关编码 ]:
2933990090

盐酸吲哚拉明海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%