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2,4-二氯嘧啶

2,4-二氯嘧啶用途

用于生产药物阿糖胞甙盐酸盐。

2,4-二氯嘧啶名称

[ CAS 号 ]:
3934-20-1

[ 中文名 ]:
2,4-二氯嘧啶

[ 英文名 ]:
2,4-Dichloropyrimidine

[英文别名 ]:

4-DichloropyriMidine
2,4-dichloro-pyrimidine
MFCD00006061
Pyrimidine, 2,4-dichloro-
2,4-Dichlorpyrimidin
2,4-Dichloropyrimidi
2,4-Dichloropyrimidine
2,6-dichloropyrimidine
dichloropyrimidine
EINECS 223-508-6

2,4-二氯嘧啶物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
209.1±0.0 °C at 760 mmHg

[ 熔点 ]:
57-61 °C(lit.)

[ 分子式 ]:
C₄H₂Cl₂N₂

[ 分子量 ]:
148.978

[ 闪点 ]:
104.3±5.4 °C

[ 精确质量 ]:
147.959503

[ PSA ]:
25.78000

[ LogP ]:
1.15

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.3±0.4 mmHg at 25°C

[ 折射率 ]:
1.559

[ 储存条件 ]:
−20°C

2,4-二氯嘧啶MSDS

2,4-二氯嘧啶安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S28A

[ 危险品运输编码 ]:
1759

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2933599090

2,4-二氯嘧啶合成路线

2,4-二氯嘧啶上下游产品

2,4-二氯嘧啶上游产品

2,4-二氯嘧啶下游产品

2,4-二氯嘧啶制备

由尿嘧啶氯化而得。将尿嘧啶、三氯氧磷和二甲苯胺加入反应锅，加热至130℃，回流约45min，稍冷却，放放碎冰中，即析出紫色固体，趁热未溶时过滤，用冰水洗涤，真空干燥，得类紫色粗品，用石油醚（沸程60-90℃）脱色、重结晶，得2,4-二氯嘧啶。

2,4-二氯嘧啶海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2,4-二氯嘧啶文献

Novel vanilloid receptor-1 antagonists: 1. Conformationally restricted analogues of trans-cinnamides.

J. Med. Chem. 50 , 3497, (2007)

The vanilloid receptor-1 (VR1 or TRPV1) is a member of the transient receptor potential (TRP) family of ion channels and plays a role as an integrator of multiple pain-producing stimuli. From a high-t...

One-pot Double Suzuki Couplings of Dichloropyrimidines.

Synthesis 2010(16) , 2721-2724, (2010)

An effective one-pot, regioselective double Suzuki coupling of 2,4-dichloropyrimidine has been developed, which enables the quick and efficient synthesis of diarylated pyrimidines. The choice of solve...

An efficient route to 4-aryl-5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine.

Org. Lett. 8(2) , 269-72, (2006)

[reaction: see text] Starting from 2,4-dichloropyrimidine, a concise synthetic route to medicinally important 4-aryl-5-pyrimidinylimidazoles is described. Sequential substitution of the 4- and 2-chlor...

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