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盐酸甲烯土霉素

盐酸甲烯土霉素用途

Methacycline盐酸盐是四环素类抗生素。

盐酸甲烯土霉素名称

[ CAS 号 ]:
3963-95-9

[ 中文名 ]:
盐酸甲烯土霉素

[ 英文名 ]:
Metacycline hydrochloride

[中文别名 ]:

美他环素

[英文别名 ]:

optimycin
adriamicina
Methacycline HCl
MFCD04972012
6-Methylene-5-hydroxytetracycline Hydrochloride
megamycine
Londomycin
globociclina
germiciclin
Methacycline hydrochloride

盐酸甲烯土霉素生物活性

[ 描述 ]:

Methacycline盐酸盐是四环素类抗生素。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. http://www.drugbank.ca/drugs/DB00931

[相关活性小分子]

盐酸甲烯土霉素物理化学性质

[ 沸点 ]:
813.8ºC at 760 mmHg

[ 分子式 ]:
C₂₂H₂₃ClN₂O₈

[ 分子量 ]:
478.880

[ 精确质量 ]:
478.114288

[ PSA ]:
181.62000

[ LogP ]:
1.06440

[ 外观性状 ]:
Crystalline Powder | Yellow

[ 储存条件 ]:
室温，干燥

盐酸甲烯土霉素MSDS

详细MSDS(安全技术说明书)

盐酸甲烯土霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QI9276000

CHEMICAL NAME :: 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5, 10,12,12a- pentahydroxy-6-methylene-1,11-dioxo-, monohydrochloride

CAS REGISTRY NUMBER :: 3963-95-9

LAST UPDATED :: 199506

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C22-H22-N2-O8.Cl-H

MOLECULAR WEIGHT :: 478.92

WISWESSER LINE NOTATION :: L E6 C666 BV FV MY CU GU LHTT&&J DQ EQ GVZ HQ IN1&1 KQ MU1 RQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,818,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 252 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 202 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,818,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,818,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 288 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 193 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,818,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84486 No. of Facilities: 57 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 344 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84486 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 330 (estimated) No. of Female Employees: 120 (estimated)

盐酸甲烯土霉素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
24/25-22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
QI9276000

[ 海关编码 ]:
29413020

盐酸甲烯土霉素上下游产品

盐酸甲烯土霉素上游产品

盐酸甲烯土霉素下游产品

盐酸甲烯土霉素制备

该品是半合成的土霉素，以土霉素为原料，先制成美他环素盐酸盐，对土霉素计，总收率41%左右。

盐酸甲烯土霉素文献

Overlapping and asymmetric functions of TCR signaling during thymic selection of CD4 and CD8 lineages.

J. Immunol. 192(11) , 5151-9, (2014)

TCR signaling plays a central role in directing developmental fates of thymocytes. Current models suggest TCR signal duration directs CD4 versus CD8 lineage development. To investigate the role of TCR...

Improvements in europium sensitized fluorimetric determination of demeclocycline and methacycline.

J. Pharm. Biomed. Anal. 37(5) , 1101-4, (2005)

Demeclocycline (DM) and methacycline (MT) have been determined by europium-sensitized fluorescence, using EDTA as co-ligand and cetyltrimethylammonium chloride as surfactant. The methods have been dev...

Simple continuous and simultaneous determination of tetracycline residues.

Res. Vet. Sci. 56(3) , 277-83, (1994)

A new continuous separation method was developed for the determination of five different tetracyclines (oxytetracycline, tetracycline, chlortetracycline, methacycline and doxycycline). A bioassay usin...

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