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IQB-782

IQB-782用途

IQB-782 是一种半胱氨酸衍生物。IQB-782 对凝血酶激活型纤溶抑制剂 (TAFI) 具有抑制作用, Ki(app) 值为 0.14 μM。IQB-782 具有较强的化痰作用。

IQB-782名称

[ CAS 号 ]:
40454-21-5

[ 英文名 ]:
IQB-782

[英文别名 ]:

IQB-782
N-amidino-L-cysteine
CYSTEINE,N-AMIDINO-,L
L-Cysteine,N-(aminoiminomethyl)
N-Amidinocysteine
EINECS 254-925-1
N-Guanyl-cysteine

IQB-782生物活性

[ 描述 ]:

IQB-782 是一种半胱氨酸衍生物。IQB-782 对凝血酶激活型纤溶抑制剂 (TAFI) 具有抑制作用, Ki(app) 值为 0.14 μM。IQB-782 具有较强的化痰作用。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

[ 靶点 ]

Ki (app): 0.14 μM (TAFI)[1]

[体外研究]

IQB-782抑制TAFI相关的羧肽酶,CPN和CPB的IC50s分别为49μM和12μM[1]。

[参考文献]

[1]. Do YH, et al. Inhibition of thrombin activatable fibrinolysis inhibitor by cysteine derivatives. Thromb Res. 2005;116(3):265-71.

[2]. Moratalla R, et al. Pharmacological study of the new mucolytic drug N-guanyl-cysteine. Arzneimittelforschung. 1986 Jun;36(6):918-23.

IQB-782物理化学性质

[ 密度 ]:
1.66g/cm3

[ 沸点 ]:
348.5ºC at 760mmHg

[ 分子式 ]:
C₄H₉N₃O₂S

[ 分子量 ]:
163.19800

[ 闪点 ]:
164.5ºC

[ 精确质量 ]:
163.04200

[ PSA ]:
138.00000

[ LogP ]:
0.04340

[ 折射率 ]:
1.673

[ 储存条件 ]:
-20°C，干燥，密封

IQB-782毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HA1680000

CHEMICAL NAME :: Cysteine, N-amidino-, L-

CAS REGISTRY NUMBER :: 40454-21-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C4-H9-N3-O2-S

MOLECULAR WEIGHT :: 163.22

WISWESSER LINE NOTATION :: ZYM&MYVQ1SH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,918,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,918,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,918,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,918,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 685 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,918,1986

IQB-782安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2930909090

IQB-782海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%