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舒利苯酮

舒利苯酮用途

Sulisobenzone是防晒霜的一种成分, 保护皮肤免受UVB和短波紫外线UVA的伤害。

舒利苯酮名称

[ CAS 号 ]:
4065-45-6

[ 中文名 ]:
2-羟基-4-甲氧基-5-磺酸二苯甲酮

[ 英文名 ]:
Sulisobenzone

[中文别名 ]:

[英文别名 ]:

Benzophenone-4
5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
EINECS 223-772-2
Sulisobenzona
sulisobenzone
Sulisobenzone Hydrate
2-Hydroxy-4-Methoxy-5-sulfonylbenzophenone(BP-4)
Sulisobenzonum
MFCD00024962

舒利苯酮生物活性

[ 描述 ]:

Sulisobenzone是防晒霜的一种成分, 保护皮肤免受UVB和短波紫外线UVA的伤害。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[相关活性小分子]

舒利苯酮物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
0°C

[ 熔点 ]:
170 °C

[ 分子式 ]:
C₁₄H₁₂O₆S

[ 分子量 ]:
308.306

[ 闪点 ]:
0°C

[ 精确质量 ]:
308.035461

[ PSA ]:
109.28000

[ LogP ]:
0.89

[ 外观性状 ]:
固体;White to Light yellow powder to crystal

[ 折射率 ]:
1.617

[ 储存条件 ]:
-20°C

[ 水溶解性 ]:
水溶性：可溶

舒利苯酮MSDS

详细MSDS(安全技术说明书)

舒利苯酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DB5044300

CHEMICAL NAME :: Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-

CAS REGISTRY NUMBER :: 4065-45-6

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C14-H12-O6-S

MOLECULAR WEIGHT :: 308.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 2(5),35,1983 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3530 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 2(5),35,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3211 No. of Facilities: 7190 (estimated) No. of Industries: 58 No. of Occupations: 35 No. of Employees: 91292 (estimated) No. of Female Employees: 38820 (estimated)

舒利苯酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
DB5044300

[ 海关编码 ]:
2914399090

舒利苯酮合成路线

详细合成路线

舒利苯酮上下游产品

舒利苯酮上游产品

舒利苯酮下游产品

舒利苯酮制备

（1）.苯二甲醚的合成将350 kg水加至反应釜中，在搅拌下加入150 kg NaOH。溶解后降温至10 ℃，加入间苯二酚110 kg，搅拌溶解。然后缓缓加入126 kg硫酸二甲酯，在26～30 ℃下反应2 h。加水稀释，分出油层，将油层用水洗至中性。除去低佛点物，蒸馏收集215～220 ℃的馏分，即为间苯二甲醚。
（2）2-羟基-4-甲氧基二苯甲酮的合成首先将300 kg氯苯加入缩合釜中，在搅拌下加入催化剂AlCl₃ 350 kg，间苯二醚120 kg。加热至80 ℃左右，缓缓加入苯甲酰氯320 kg。回流4～6 h，冷却，水解，蒸出溶剂，冷却，结晶，干燥，得2-羟基-4-甲氧基二苯甲酮。
（3）.2-羟基-4-甲氧基-5-磺酸基二苯丙酮的合成首先往磺化釜中加入93%的硫酸，在搅拌下慢慢加入2-羟基-4-甲氧基二苯甲酮，在110 ℃左右反应4～6 h，冷却，结晶，甩干，重结晶即为成品。反应式如下：

舒利苯酮海关

[ 海关编码 ]: 2914399090

[ 中文概述 ]:
2914399090. 其他不含其他含氧基的芳香酮. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

舒利苯酮文献

Altered UV absorbance and cytotoxicity of chlorinated sunscreen agents.

Cutan. Ocul. Toxicol. 31(4) , 273-9, (2012)

Sunscreens are widely utilized due to the adverse effects of ultraviolet (UV) radiation on human health. The safety of their active ingredients as well as that of any modified versions generated durin...

iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis.

Nat. Commun. 5 , 4028, (2014)

Mutations in the acid β-glucocerebrosidase (GBA1) gene, responsible for the lysosomal storage disorder Gaucher's disease (GD), are the strongest genetic risk factor for Parkinson's disease (PD) known ...

Transcriptional expression of myelin basic protein in oligodendrocytes depends on functional syntaxin 4: a potential correlation with autocrine signaling.

Mol. Cell. Biol. 35(4) , 675-87, (2015)

Myelination of axons by oligodendrocytes is essential for saltatory nerve conduction. To form myelin membranes, a coordinated synthesis and subsequent polarized transport of myelin components are nece...

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