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没食子儿茶素没食子酸酯

没食子儿茶素没食子酸酯用途

(-)-Gallocatechin gallate 是茶中的多酚类物质,具有抗癌作用。

没食子儿茶素没食子酸酯名称

[ CAS 号 ]:
4233-96-9

[ 中文名 ]:
没食子酸儿茶素没食子酸酯

[ 英文名 ]:
(-)-Gallocatechin gallate

[中文别名 ]:

[英文别名 ]:

(−)-Gallocatechin gallate
(-)-Gallocatechin gallate
Gallocatechin gallate
MFCD00214298
GCG
(-)-Gallocatechin 3-O-gallate

没食子儿茶素没食子酸酯生物活性

[ 描述 ]:

(-)-Gallocatechin gallate 是茶中的多酚类物质,具有抗癌作用。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

天然产物 >> 黄酮类化合物

[体外研究]

(-)-没食子酸没食子酸酯的量在不同阶段的叶子中没有差异,并且含量相对较低[1]。 (-)-没食子儿茶素没食子酸酯与活性儿茶素((-)-表没食子儿茶素没食子酸酯)对PC-9细胞诱导凋亡和抑制细胞生长具有协同作用。 (-)-没食子儿茶素没食子酸酯对α-葡萄糖苷酶和DPPH有抑制作用,IC50分别为30.2μM和12.2μg/ mL [2]。

[细胞实验]

通过测量细胞将MTT代谢成紫色甲dye染料的能力来检查细胞活力。将人肝癌HepG2细胞维持在补充有10％胎牛血清，100单位/ mL青霉素和50单位/ mL链霉素的DMEM培养基中，在37℃下在具有5％CO 2气氛的潮湿培养箱中。将细胞接种在96孔组织培养板中24小时，然后与不同浓度的测试化合物一起温育72小时。温育后，加入25μL在5mg / mL PBS中的MTT并孵育4小时。吸出培养基并用150μL二甲基亚砜（DMSO）代替以溶解甲salt盐。使用微孔板分光光度计在570nm下测量反映细胞生长条件的甲product溶液的颜色强度。

[参考文献]

[1]. Zhang LQ, et al. Accumulation of catechins and expression of catechin synthetic genes in Camellia sinensis at different developmental stages. Bot Stud. 2016 Dec;57(1):31.

[2]. Zhou H, et al. C-geranylated flavanones from YingDe black tea and their antioxidant and α-glucosidase inhibition activities. Food Chem. 2017 Nov 15;235:227-233.

[相关活性小分子]

没食子儿茶素没食子酸酯物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
909.1±65.0 °C at 760 mmHg

[ 分子式 ]:
C₂₂H₁₈O₁₁

[ 分子量 ]:
458.372

[ 闪点 ]:
320.0±27.8 °C

[ 精确质量 ]:
458.084900

[ PSA ]:
197.37000

[ LogP ]:
2.08

[ 外观性状 ]:
白色到粉色粉末

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.857

[ 储存条件 ]:
2-8°C

没食子儿茶素没食子酸酯MSDS

详细MSDS(安全技术说明书)

没食子儿茶素没食子酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH9000000

CHEMICAL NAME :: Benzoic acid, 3,4,5-trihydroxy-, 3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)- 2H-1-benzopyran-3-yl ester, (2S-trans)-

CAS REGISTRY NUMBER :: 4233-96-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H18-O11

MOLECULAR WEIGHT :: 458.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-944

没食子儿茶素没食子酸酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DH9000000

没食子儿茶素没食子酸酯制备

绿茶提取物。

没食子儿茶素没食子酸酯文献

Identification and quantification of phytochemicals in nutraceutical products from green tea by UHPLC-Orbitrap-MS.

Food Chem. 173 , 607-18, (2014)

A method has been developed and validated for the simultaneous detection and quantification of phytochemicals in nutraceutical products obtained from green tea. For that purpose, ultra-high performanc...

An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.

J. Nat. Prod. 73 , 1193-5, (2010)

Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple fo...

Comparative proteomic analysis using 2DE-LC-MS/MS reveals the mechanism of Fuzhuan brick tea extract against hepatic fat accumulation in rats with nonalcoholic fatty liver disease.

Electrophoresis 36 , 2002-16, (2015)

Fuzhuan brick tea has received increasing attention in recent years owing to its benefits for nonalcoholic fatty liver disease (NAFLD) and associated metabolic syndrome. For exploring the ameliorative...

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