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氟尼辛葡甲胺

氟尼辛葡甲胺用途

Flunixin Meglumine是COX抑制剂,具有抗炎退热活性。

氟尼辛葡甲胺名称

[ CAS 号 ]:
42461-84-7

[ 中文名 ]:
氟胺烟酸葡甲胺盐

[ 英文名 ]:
Flunixin Meglumine

[中文别名 ]:

氟尼辛葡甲胺

[英文别名 ]:

Flunixin meglumine
MFCD01725419
EINECS 255-836-0
FLUNIXIN N-METHYLGLUCAMINE
Flunixin (meglumine)

氟尼辛葡甲胺生物活性

[ 描述 ]:

Flunixin Meglumine是COX抑制剂,具有抗炎退热活性。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[ 靶点 ]

COX-2:0.4 nM (IC50)

COX-1:17 nM (IC50)

[参考文献]

[1]. Cheng Z, et al. Measurement of cyclooxygenase inhibition in vivo: a study of two non-steroidal anti-inflammatory drugs in sheep. Inflammation. 1998 Aug;22(4):353-66.

[2]. Bryant, C.E., B.A. Farnfield, and H.J. Janicke, Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B. Am J Vet Res, 2003. 64(2): p. 211-5.

[相关活性小分子]

氟尼辛葡甲胺物理化学性质

[ 密度 ]:
1.403 g/cm3

[ 沸点 ]:
378.7ºC at 760 mmHg

[ 熔点 ]:
136-138ºC

[ 分子式 ]:
C₂₁H₂₈F₃N₃O₇

[ 分子量 ]:
491.458

[ 闪点 ]:
182.8ºC

[ 精确质量 ]:
491.187927

[ PSA ]:
175.40000

[ LogP ]:
0.95620

[ 外观性状 ]:
固体

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
H2O: freely soluble | soluble

氟尼辛葡甲胺MSDS

详细MSDS(安全技术说明书)

氟尼辛葡甲胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ4367000

CHEMICAL NAME :: D-Glucitol, 1-deoxy-1-(methylamino)-, 2-((2-methyl-3-(trifluoromethyl)phenyl)amino)-3- pyridinecarboxylate (salt)

CAS REGISTRY NUMBER :: 42461-84-7

LAST UPDATED :: 199403

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H11-F3-N2-O2.C7-H17-N-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 39600 ug/kg/12D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :: JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- Volume(issue)/page/year: 202,71,1993

氟尼辛葡甲胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LZ4367000

氟尼辛葡甲胺文献

Pharmacokinetics and effects on thromboxane B2 production following intravenous administration of flunixin meglumine to exercised thoroughbred horses.

J. Vet. Pharmacol. Ther. 38 , 313-20, (2015)

Flunixin meglumine is commonly used in horses for the treatment of musculoskeletal injuries. The current ARCI threshold recommendation is 20 ng/mL when administered at least 24 h prior to race time. I...

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Registered report: the microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44.

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