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氟米龙

氟米龙用途

Fluorometholone 是一种合成糖皮质激素,能作为糖皮质激素受体 (glucocorticoid receptor) 激动剂,具有抗炎和抗过敏特性。Fluorometholone 可用于缓解干眼症。

氟米龙名称

[ CAS 号 ]:
426-13-1

[ 中文名 ]:
氟米龙

[ 英文名 ]:
fluoromethalone

[中文别名 ]:

[英文别名 ]:

EINECS 207-041-5
Fluoromethalone
21-Desoxy-6a-methyl-9a-fluoroprednisolone
Fluormetholon
fluorometholone
FLAREX
Efflumidex
21-Desoxy-9a-fluoro-6a-methylprednisolone
Loticort
MFCD00056461

氟米龙生物活性

[ 描述 ]:

Fluorometholone 是一种合成糖皮质激素,能作为糖皮质激素受体 (glucocorticoid receptor) 激动剂,具有抗炎和抗过敏特性。Fluorometholone 可用于缓解干眼症。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体

[ 靶点 ]

glucocorticoid receptor[1]

[体外研究]

氟甲龙(25-100nm；12h,24h)通过激活糖皮质激素受体,增加结膜和角膜上皮细胞中MUC1、MUC4、MUC16和MUC19的基因表达[1]。

[参考文献]

[1]. Jonathan Taniguchi, et al. Fluorometholone Modulates Gene Expression of Ocular Surface Mucins. Acta Ophthalmol. 2019 Dec;97(8):e1082-e1088.

氟米龙物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
527.1±50.0 °C at 760 mmHg

[ 熔点 ]:
292 - 303ºC

[ 分子式 ]:
C₂₂H₂₉FO₄

[ 分子量 ]:
376.462

[ 闪点 ]:
272.6±30.1 °C

[ 精确质量 ]:
376.204987

[ PSA ]:
74.60000

[ LogP ]:
2.02

[ 外观性状 ]:
固体;White to Orange to Green powder to crystal

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 折射率 ]:
1.574

[ 储存条件 ]:
避免光

氟米龙MSDS

氟米龙毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU3834100

CHEMICAL NAME :: Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6-alpha,11-beta)-

CAS REGISTRY NUMBER :: 426-13-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C22-H29-F-O4

MOLECULAR WEIGHT :: 376.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2349,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 443 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,981,1990

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2349,1974 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2800 ug/kg/28D-I

TOXIC EFFECTS :: Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2349,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3684 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 82 (estimated) No. of Female Employees: 14 (estimated)

氟米龙安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TU3834100

[ 海关编码 ]:
2937229000

氟米龙合成路线

氟米龙上下游产品

氟米龙上游产品

氟米龙下游产品

氟米龙海关

[ 海关编码 ]: 2937229000

氟米龙文献

Peripheral deep anterior lamellar keratoplasty using a cryopreserved donor cornea for Terrien's marginal degeneration.

J. Zhejiang Univ. Sci. B 15(12) , 1055-63, (2014)

To evaluate the clinical efficacy of peripheral deep anterior lamellar keratoplasty (DALK) using a cryopreserved donor cornea for Terrien's marginal degeneration (TMD).Thirty-one eyes of 27 patients w...

Comparison of Corneal Biomechanical Characteristics After Surface Ablation Refractive Surgery and Novel Lamellar Refractive Surgery.

Cornea 34 , 1441-6, (2015)

To investigate and compare corneal biomechanical changes in the form of corneal hysteresis (CH) and corneal resistance factor (CRF) after small-incision lenticule extraction (SMILE) and laser-assisted...

Big bubble deep anterior lamellar keratoplasty for management of deep fungal keratitis.

J. Ophthalmol. 2014 , 209759, (2014)

Objective. To evaluate the therapeutic effect of big bubble deep anterior lamellar keratoplasty (DALK) in patients with deep fungal keratitis. Methods.Consecutive patients who had DALK for deep fungal...

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氟米龙