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DL-苏-beta-羟基天冬氨酸

DL-苏-beta-羟基天冬氨酸用途

DL -苏式-β-羟基天冬氨酸 (THA) 是一种谷氨酸摄取抑制剂。

DL-苏-beta-羟基天冬氨酸名称

[ CAS 号 ]:
4294-45-5

[ 中文名 ]:
(2S,3S)-2-氨基-3-羟基琥珀酸

[ 英文名 ]:
DL-Threo-beta-Hydroxyaspartic Acid

[中文别名 ]:

DL-苏-beta-羟基天冬氨酸

[英文别名 ]:

DL-THREO-β-HYDROXYASPARTIC ACID
threo-2-Amino-3-hydroxysuccinic acid
DL-Threo-beta-Hydroxyaspartic Acid

DL-苏-beta-羟基天冬氨酸生物活性

[ 描述 ]:

DL-threo-3-Hydroxyaspartic acid 是一种谷氨酸摄取抑制剂,可以阻断插管 SD 大鼠体内的谷氨酸转运。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. A Klegeris,et al. Regulation of glutamate in cultures of human monocytic THP-1 and astrocytoma U-373 MG cells.J Neuroimmunol.1997 Sep;78(1-2):152-61.

[2]. Jessica Darman, et al. Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity.J Neurosci. 2004 Aug 25;24(34):7566-75.

DL-苏-beta-羟基天冬氨酸物理化学性质

[ 密度 ]:
1.738 g/cm3

[ 沸点 ]:
368.7ºC at 760 mmHg

[ 熔点 ]:
>230ºC dec

[ 分子式 ]:
C₄H₇NO₅

[ 分子量 ]:
149.10200

[ 闪点 ]:
176.8ºC

[ 精确质量 ]:
149.03200

[ PSA ]:
120.85000

[ 外观性状 ]:
灰白色固体

[ 折射率 ]:
1.583

[ 储存条件 ]:
20°C

DL-苏-beta-羟基天冬氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2922509090

DL-苏-beta-羟基天冬氨酸上下游产品

DL-苏-beta-羟基天冬氨酸上游产品

DL-苏-beta-羟基天冬氨酸下游产品

DL-苏-beta-羟基天冬氨酸海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

DL-苏-beta-羟基天冬氨酸文献

The SLC1 high-affinity glutamate and neutral amino acid transporter family.

Mol. Aspects Med. 34(2-3) , 108-20, (2013)

Glutamate transporters play important roles in the termination of excitatory neurotransmission and in providing cells throughout the body with glutamate for metabolic purposes. The high-affinity gluta...

A concise, asymmetric synthesis of (2R,3R)-3-hydroxyaspartic acid.

Amino Acids 35(2) , 507-10, (2008)

3-Hydroxyaspartic acid and its derivatives are found both in the free form and as peptide constituents in various microorganisms and fungi. Considering the biological importance of this amino acid and...

Insights into the mechanism of Pseudomonas dacunhae aspartate beta-decarboxylase from rapid-scanning stopped-flow kinetics.

Biochemistry 49 , 5066-73, (2010)

The mechanism of wild-type and R37A mutant Pseudomonas dacunhae aspartate beta-decarboxylase (ABDC) was studied by rapid-scanning stopped-flow spectrophotometry. Mixing wild-type ABDC with 50 mM disod...

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