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DPO-1,KV1.5和IKurcurrent的通道阻滞剂

DPO-1,KV1.5和IKurcurrent的通道阻滞剂用途

DPO-1是电压门控钾通道亚型Kv1的有效抑制剂。5和超快速延迟整流钾电流阻断剂。DPO-1可预防房性心律失常[1][2]。

DPO-1,KV1.5和IKurcurrent的通道阻滞剂名称

[ CAS 号 ]:
43077-30-1

[ 中文名 ]:
DPO-1,KV1.5和IKurcurrent的通道阻滞剂

[ 英文名 ]:
DPO-1

[英文别名 ]:

DPO-1
HMS3269O11
neomenthyldiphenylphosphine oxide
Neomenthyldiphenylphosphin-oxid
HMS3261N07

DPO-1,KV1.5和IKurcurrent的通道阻滞剂生物活性

[ 描述 ]:

DPO-1是电压门控钾通道亚型Kv1的有效抑制剂。5和超快速延迟整流钾电流阻断剂。DPO-1可预防房性心律失常[1][2]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 跨膜转运 >> 钾通道

[参考文献]

[1]. Lagrutta A, et al. Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating delayed rectifier potassium current. J Pharmacol Exp Ther. 2006 Jun;317(3):1054-63.

[2]. Stump GL, et al. In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide. J Pharmacol Exp Ther. 2005 Dec;315(3):1362-7.

DPO-1,KV1.5和IKurcurrent的通道阻滞剂物理化学性质

[ 密度 ]:
1.054g/cm3

[ 沸点 ]:
434.966ºC at 760 mmHg

[ 分子式 ]:
C₂₂H₂₉OP

[ 分子量 ]:
340.43900

[ 闪点 ]:
216.86ºC

[ 精确质量 ]:
340.19600

[ PSA ]:
26.88000

[ LogP ]:
5.46130

[ 折射率 ]:
1.547

[ 储存条件 ]:
-20°C，避光

DPO-1,KV1.5和IKurcurrent的通道阻滞剂MSDS

DPO-1,KV1.5和IKurcurrent的通道阻滞剂安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2902909090

DPO-1,KV1.5和IKurcurrent的通道阻滞剂合成路线

DPO-1,KV1.5和IKurcurrent的通道阻滞剂上下游产品

DPO-1,KV1.5和IKurcurrent的通道阻滞剂上游产品

DPO-1,KV1.5和IKurcurrent的通道阻滞剂下游产品

DPO-1,KV1.5和IKurcurrent的通道阻滞剂海关

[ 海关编码 ]: 2902909090

[ 中文概述 ]:
2902909090. 其他芳香烃. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:2.0%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量

[ Summary ]:
2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

DPO-1,KV1.5和IKurcurrent的通道阻滞剂文献

Polycomb-dependent repression of the potassium channel-encoding gene KCNA5 promotes cancer cell survival under conditions of stress.

Oncogene 34 , 4591-600, (2015)

Relapse after clinical remission remains a leading cause of cancer-associated death. Although the mechanisms of tumor relapse are complex, the ability of cancer cells to survive physiological stress i...

HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction.

Cardiovasc. Res. 109 , 115-30, (2015)

Hypoxic conditions stimulate pulmonary vasoconstriction and vascular remodelling, both pathognomonic changes in pulmonary arterial hypertension (PAH). The secreted protein thrombospondin-1 (TSP1) is i...

Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells.

PLoS ONE 8 , e64629, (2013)

Diphenyl phosphine oxide-1 (DPO-1) is a potent Kv1.5 channel inhibitor that has therapeutic potential for the treatment of atrial fibrillation. Many other Kv1.5 channel blockers also potently inhibit ...

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