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2-(4'-甲基氨基苯基)苯并噻唑

2-(4'-甲基氨基苯基)苯并噻唑用途

BTA-1是硫黄素-T的不带电衍生物。BTA-1对Aβ纤维有很高的亲和力,并显示出非常好的大脑进入和清除能力[1]。

2-(4'-甲基氨基苯基)苯并噻唑名称

[ CAS 号 ]:
439858-28-3

[ 中文名 ]:
2-(4’-甲基氨基苯基)苯并噻唑

[ 英文名 ]:
BTA-1

[英文别名 ]:

2-(4'-Methylaminophenyl)benzothiazole
BTA-1
Benzo-Thiazole-Aniline-1-Methyl

2-(4'-甲基氨基苯基)苯并噻唑生物活性

[ 描述 ]:

BTA-1是硫黄素-T的不带电衍生物。BTA-1对Aβ纤维有很高的亲和力,并显示出非常好的大脑进入和清除能力[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Klunk WE, et al. The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component. J Neurosci. 2003;23(6):2086-2092.

2-(4'-甲基氨基苯基)苯并噻唑物理化学性质

[ 分子式 ]:
C₁₄H₁₂N₂S

[ 分子量 ]:
240.32300

[ 精确质量 ]:
240.07200

[ PSA ]:
53.16000

[ LogP ]:
4.07800

[ 储存条件 ]:
2-8℃

2-(4'-甲基氨基苯基)苯并噻唑MSDS

详细MSDS(安全技术说明书)

2-(4'-甲基氨基苯基)苯并噻唑安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934200090

2-(4'-甲基氨基苯基)苯并噻唑海关

[ 海关编码 ]: 2934200090

[ 中文概述 ]:
2934200090. 其他含一个苯并噻唑环系的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934200090. other compounds containing in the structure a benzothiazole ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-(4'-甲基氨基苯基)苯并噻唑文献

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques.

Nat. Commun. 6 , 6176, (2015)

In Alzheimer's disease (AD), β-amyloid (Aβ) plaques are tightly enveloped by microglia processes, but the significance of this phenomenon is unknown. Here we show that microglia constitute a barrier w...

The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component.

J. Neurosci. 23 , 2086-2092, (2003)

2-(4'-methylaminophenyl)benzothiazole (BTA-1) is an uncharged derivative of thioflavin-T that has high affinity for Abeta fibrils and shows very good brain entry and clearance. In this study, we asked...

A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.

Bioorg. Med. Chem. Lett. 12 , 295-298, (2002)

The synthesis of a new lipophilic thioflavin-T analogue (2-[4' -(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [(11)C]-labeled 6 in control ...

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