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蛇孢菌素 A

蛇孢菌素 A用途

Ophiobolin A 是一种真菌代谢产物和植物毒素,是一种有效的、不可逆的钙调素激活环核苷酸磷酸二酯酶的抑制剂,其IC50 值为 9 μM。Ophiobolin A 具有抗菌和抗癌作用。

蛇孢菌素 A名称

[ CAS 号 ]:
4611-05-6

[ 中文名 ]:
蠕孢甲壳素禾长蠕孢菌

[ 英文名 ]:
(+)-Ophiobolin A

[英文别名 ]:

COCHLIOBOLIN A
Ophiobolin A
cochliobolin
ophiobolin
Ophiobolin,Helminthosporium sp.
orphiobolin A

蛇孢菌素 A生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)

研究领域 >> 感染

[ 靶点 ]

IC50: 9 μM (calmodulin-activated cyclic nucleotide phosphodiesterase)[1].

[参考文献]

[1]. Leung PC, et al. Ophiobolin A. A natural product inhibitor of calmodulin. J Biol Chem. 1984 Mar 10;259(5):2742-7

蛇孢菌素 A物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
539.4±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₅H₃₆O₄

[ 分子量 ]:
400.551

[ 闪点 ]:
177.8±23.6 °C

[ 精确质量 ]:
400.261353

[ PSA ]:
63.60000

[ LogP ]:
3.75

[ 蒸汽压 ]:
0.0±3.3 mmHg at 25°C

[ 折射率 ]:
1.554

[ 储存条件 ]:
-20°C，密闭，干燥

蛇孢菌素 A毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RL1576000

CHEMICAL NAME :: Ophiobola-7,19-dien-25-al, 14,18-epoxy-3-hydroxy-5-oxo-, (18R)-

CAS REGISTRY NUMBER :: 4611-05-6

LAST UPDATED :: 198211

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C25-H36-O4

MOLECULAR WEIGHT :: 400.61

WISWESSER LINE NOTATION :: L C585 FV LX HUTJ A1 DQ D1 HVH L-& BT5OXTJ C1 E1UY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 238 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,143,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,143,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 73 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,143,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,143,1981

蛇孢菌素 A安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H312 + H332

[ 警示性声明 ]:
Missing Phrase - N15.00950417-P261-P280

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/21/22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ RTECS号 ]:
RL1576000