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4-氯丁酰氯

4-氯丁酰氯用途

【用途一】
用作医药中间体，用于生产氟哌啶醇、三氯哌丁苯等
【用途二】
γ-氯代丁酰氯是植物生长调节剂抗倒酯的中间体，也是医药氟哌啶醇的中间体。

4-氯丁酰氯名称

[ CAS 号 ]:
4635-59-0

[ 中文名 ]:
4-氯丁酰氯

[ 英文名 ]:
4-Chlorobutyryl chloride

[中文别名 ]:

[英文别名 ]:

4-Chlorobutanoyl chloride
Butanoyl chloride, 4-chloro-
γ-Chlorobutyryl chloride
MFCD00000754
4-Chlorobutyryl chloride
4-Chlorobutyrylchloride
EINECS 225-059-1

4-氯丁酰氯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
174.3±13.0 °C at 760 mmHg

[ 熔点 ]:
-47 °C

[ 分子式 ]:
C₄H₆Cl₂O

[ 分子量 ]:
140.996

[ 闪点 ]:
70.2±20.2 °C

[ 精确质量 ]:
139.979568

[ PSA ]:
17.07000

[ LogP ]:
1.44

[ 外观性状 ]:
透明液体

[ 蒸汽压 ]:
1.2±0.3 mmHg at 25°C

[ 折射率 ]:
1.442

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (分解)

4-氯丁酰氯MSDS

4-氯丁酰氯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EM1406000

CHEMICAL NAME :: Butanoyl chloride, 4-chloro-

CAS REGISTRY NUMBER :: 4635-59-0

LAST UPDATED :: 199710

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C4-H6-Cl2-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 650 mg/m3/4H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570772

4-氯丁酰氯安全信息

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H314-H330

[ 警示性声明 ]:
P260-P280-P284-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R22;R23;R35

[ 安全声明 (欧洲) ]:
S26-S28-S36/37/39-S45-S28A

[ 危险品运输编码 ]:
UN 3390 6.1/PG 1

[ WGK德国 ]:
1

[ RTECS号 ]:
EM1406000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29159080

4-氯丁酰氯合成路线

4-氯丁酰氯上下游产品

4-氯丁酰氯上游产品

4-氯丁酰氯下游产品

4-氯丁酰氯制备

1.其制备方法是将丁内酯、无水氯化锌和氯化亚砜置于反应瓶中，于55℃搅拌12h，减压蒸馏收集产品。

由γ-丁内酯经氯化而得。将γ-丁内酯和氯化锌搅拌升温，在55-60℃下反应1h。于60℃慢慢加入氯化亚砜，反应2h。在5-6h内升温至80℃。静置过夜，取上部清液常压蒸馏后再重蒸1次，收集馏分得4-氯丁酰氯。

2.制法：

于装有搅拌器、温度计、滴液漏斗、回流冷凝器（连一导气管吸收氯化氢和二氧化硫）的反应瓶中，加入γ-丁内酯（2）85g（1mol），新熔融过的氯化锌33g（0.24mol），滴加氯化亚砜143g（1.2mol），约20min加完。慢慢升温至60～70℃，搅拌反应12h，水泵抽去酸气后，用油泵减压蒸馏，收集69～71℃/1.4kPa的馏分，得4-氯丁酰氯（1）105g，收率75%。nD²⁵1.465～1.4607。

4-氯丁酰氯海关

[ 海关编码 ]: 2915900090

[ 中文概述 ]:
2915900090. 其他饱和无环一元羧酸及其酸酐（酰卤、过氧）化物、过氧酸及其卤化、硝化、磺化、亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

4-氯丁酰氯文献

N-Chloroacyl-6-O-triphenylmethylchitosans: useful intermediates for synthetic modifications of chitosan.

Biomacromolecules 6(2) , 858-63, (2005)

An efficient synthetic route was developed for the mild chloroacylation of chitosan with different chloroacyl chlorides. Full N-chloroacylation was obtained with this procedure without any O-acylation...

Radiosynthesis of (11)C-Levetiracetam: A Potential Marker for PET Imaging of SV2A Expression.

ACS Med. Chem. Lett. 5(10) , 1152-5, (2014)

The multistep preparation of (11)C-levetiracetam ((11)C-LEV) was carried out by a one-pot radiosynthesis with 8.3 ± 1.6% (n = 8) radiochemical yield in 50 ± 5.0 min. Briefly, the propionaldehyde was c...

Multikilogram-scale synthesis of a biphenyl carboxylic acid derivative using a Pd/C-mediated suzuki coupling approach. Ennis DS, et al.

Org. Process Res. Dev. 3(4) , 248-52, (1999)

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