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3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺

3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺用途

SB-366791是一种有效的选择性vanilloid 受体 (VR1/TRPV1) 拮抗剂,IC50为5.7±1.2 nM

3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺名称

[ CAS 号 ]:
472981-92-3

[ 中文名 ]:
3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺

[ 英文名 ]:
SB-366791

[英文别名 ]:

N-(3-Methoxyphenyl)-4-chlorocinnamide
SB-366791

3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺生物活性

[ 描述 ]:

SB-366791是一种有效的选择性vanilloid 受体 (VR1/TRPV1) 拮抗剂,IC50为5.7±1.2 nM

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 癌症

[参考文献]

[1]. M.J. Gunthorpe et al. Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology, 2004 Jan, 46(1):133-49.

[2]. Gavva NR et al. Proton Activation Does Not Alter Antagonist Interaction with the Capsaicin-Binding Pocket of TRPV1. Mol Pharmacol, 2005 Dec, 68(6), 1524-33.

[相关活性小分子]

辣椒碱 | 辣椒平 | 5-(N-乙基-N-异丙基)阿米洛利 | 氯化二亚苯基碘鎓 | 2-(1,3-二甲基-2,6-二氧代-2,3-二氢-1H-嘌呤-7(6H)-基)-N-(4-异丙基苯基)乙酰胺 | 1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑 | HC-067047 | AMG9810 | GSK1016790A | SAR7334 | PF-4840154 | RN-1734 | AMG 517 | 冰素 | ML204

3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
494.2±45.0 °C at 760 mmHg

[ 熔点 ]:
169 °C

[ 分子式 ]:
C₁₆H₁₄ClNO₂

[ 分子量 ]:
287.741

[ 闪点 ]:
252.7±28.7 °C

[ 精确质量 ]:
287.071320

[ PSA ]:
38.33000

[ LogP ]:
4.52

[ 外观性状 ]:
固体;White to Light yellow to Light orange powder to crystal

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.650

[ 储存条件 ]:
-20℃

3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺MSDS

详细MSDS(安全技术说明书)

3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺文献

Involvement of TRPV1 and TRPA1 in incisional intraoral and extraoral pain.

J. Dent. Res. 94(3) , 446-54, (2015)

Thermal and mechanical hypersensitivity in the injured region is a common complication. Although it is well known clinically that thermal and mechanical sensitivity of the oral mucosa is different fro...

Supraspinal TRPV1 modulates the emotional expression of abdominal pain.

Pain 155(10) , 2153-60, (2014)

The transient receptor potential vanilloid receptor type-1 (TRPV1) is critically involved in peripheral nociceptive processes of somatic and visceral pain. However, the role of the capsaicin receptor ...

Acid solution is a suitable medium for introducing QX-314 into nociceptors through TRPV1 channels to produce sensory-specific analgesic effects.

PLoS ONE 6(12) , e29395, (2011)

Previous studies have demonstrated that QX-314, an intracellular sodium channel blocker, can enter into nociceptors through capsaicin-activated TRPV1 or permeation of the membrane by chemical enhancer...

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