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9-菲酚

9-菲酚用途

9-菲(9-羟基菲)是一种高效、选择性的人体TRPM4抑制剂,IC50为20μM。9-菲可用于研究缺血再灌注损伤[1][2]。

9-菲酚名称

[ CAS 号 ]:
484-17-3

[ 中文名 ]:
9-羟基菲

[ 英文名 ]:
9-Phenanthrol

[中文别名 ]:

[英文别名 ]:

9-Phenanthrol
Phenanthren-9-ol
MFCD00082298
EINECS 207-602-4
9-Phenanthrenol

9-菲酚生物活性

[ 描述 ]:

9-菲(9-羟基菲)是一种高效、选择性的人体TRPM4抑制剂,IC50为20μM。9-菲可用于研究缺血再灌注损伤[1][2]。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 心血管疾病

[参考文献]

[1]. Wang J, et, al. 9-Phenanthrol, a TRPM4 inhibitor, protects isolated rat hearts from ischemia-reperfusion injury. PLoS One. 2013 Jul 25;8(7):e70587.

9-菲酚物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
404.5±14.0 °C at 760 mmHg

[ 熔点 ]:
139-143ºC

[ 分子式 ]:
C₁₄H₁₀O

[ 分子量 ]:
194.23

[ 闪点 ]:
197.7±12.0 °C

[ 精确质量 ]:
194.073166

[ PSA ]:
20.23000

[ LogP ]:
3.94

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.754

[ 储存条件 ]:
Refrigerator

9-菲酚MSDS

9-菲酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SF8288000

CHEMICAL NAME :: 9-Phenanthrol

CAS REGISTRY NUMBER :: 484-17-3

BEILSTEIN REFERENCE NO. :: 2047057

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H10-O

MOLECULAR WEIGHT :: 194.24

WISWESSER LINE NOTATION :: L B666J HQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - hamster Kidney

DOSE/DURATION :: 5 mg/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 20,1297,1971

9-菲酚安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
SF8288000

[ 海关编码 ]:
2906299090

9-菲酚合成路线

9-菲酚海关

[ 海关编码 ]: 2906299090

[ 中文概述 ]:
2906299090 其他芳香醇. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

9-菲酚文献

Detection of polycyclic aromatic hydrocarbons (PAHs) in raw menhaden fish oil using fluorescence spectroscopy: Method development.

Environ. Toxicol. Chem. 34 , 1946-58, (2015)

Raw menhaden fish oil was developed for biomonitoring polycyclic aromatic hydrocarbons (PAHs) using fluorescence spectroscopy. Menhaden (Genus Brevoortia) were collected in 2010 and/or 2011 from Delaw...

Shear stress induces a longitudinal Ca(2+) wave via autocrine activation of P2Y1 purinergic signalling in rat atrial myocytes.

J. Physiol. 593 , 5091-109, (2015)

Atrial myocytes are exposed to shear stress during the cardiac cycle and haemodynamic disturbance. In response, they generate a longitudinally propagating global Ca(2+) wave. Here, we investigated the...

Application of nano-sized multi-template imprinted polymer for simultaneous extraction of polycyclic aromatic hydrocarbon metabolites in urine samples followed by ultra-high performance liquid chromatographic analysis.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 985 , 110-8, (2015)

Nano-sized molecularly imprinted polymer (nMIP) was synthesized through precipitation polymerization method and used it as solid phase extraction (SPE) sorbent for the selective and simultaneous extra...

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