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侧金盏花醇

侧金盏花醇用途

Ribitol 是一种戊糖醇,可通过核糖还原形成。在酿酒酵母 (Saccharomyces cerevisiae) 中增强 D-葡萄糖转向戊糖磷酸途径,可用于生产 D-核糖和核糖醇。

侧金盏花醇名称

[ CAS 号 ]:
488-81-3

[ 中文名 ]:
阿东糖醇

[ 英文名 ]:
Ribitol

[中文别名 ]:

[英文别名 ]:

(2R,3s,4S)-1,2,3,4,5-Pentanpentol
adonitol
ADONIT
ADONITE
ADONITOL(RG)
(2R,3s,4S)-pentane-1,2,3,4,5-pentol
RIBITO
Adonito
D-erythro-Pentitol
MFCD00064291

侧金盏花醇生物活性

[ 描述 ]:

Ribitol 是一种戊糖醇,可通过核糖还原形成。在酿酒酵母 (Saccharomyces cerevisiae) 中增强 D-葡萄糖转向戊糖磷酸途径,可用于生产 D-核糖和核糖醇。

[ 相关类别 ]:

研究领域 >> 其他

天然产物 >> 糖和糖苷

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

核糖醇是还原糖[1]。研究了酿酒酵母的磷酸葡萄糖异构酶缺陷型(pgi1)菌株,以通过戊糖磷酸途径的中间体从D-葡萄糖产生D-核糖和核糖醇。编码酿酒酵母的磷酸磷酸酶(DOG1)的基因的过表达是产生D-核糖和核糖醇所必需的。比较工程菌株从D-葡萄糖产生PPP衍生的5-碳化合物Ribitol和D-核糖的能力[2]。

[激酶实验]

高效液相色谱（HPLC）分析使用快速酸性柱（100×7.8 mm）和HPX-87H离子排斥柱（300 mm×7.8 mm）与2.5 mM H2SO4水溶液作为移动设备进行相流速为0.3 mL / min，温度为55°C。该方法能够定量D-葡萄糖，乙醇，甘油，D-木酮糖，核糖醇和木糖醇。 D-核糖，D-核酮糖和D-阿拉伯糖醇在Aminex HPX-87H柱上共洗脱。 Dionex ICS-3000的CarboPac MA-1柱用于分析代表性培养物上清液样品中阿拉伯糖醇和木糖醇的存在。样品在柱温30℃下用480mM NaOH以0.4mL / min的流速进行。 CarboPac MA-1柱将D-阿拉伯糖醇与D-核糖和D-核酮糖分开，但碱性条件降解D-核酮糖干扰D-核糖的定量。在100mM磷酸钠缓冲液pH下用玻璃珠破坏酵母细胞7.0含有苯甲基磺酰氟和胃蛋白酶抑制剂A，终浓度分别为0.17mg / mL和0.01mg / mL。在0.5M三乙醇胺pH7.7和2mM NADH的反应缓冲液中测量NAD +依赖性Gdh2p的活性。加入细胞裂解物后，通过加入α-酮戊二酸（100mM）和NH 4 Cl（200mM）的混合物开始反应，终浓度分别为2.4mM和4.9mM。测量GapB活性。不久，反应混合物是500mM三乙醇胺pH 7.8,1mM ATP，2mM MgCl2,200μMNADPH和10μg/ mL磷酸甘油酸激酶。加入3-磷酸甘油酸盐至终浓度为5mM以开始反应。使用Cobas Mira Plus自动分析仪[2]进行活动测量。

[参考文献]

[1]. Praissman JL, et al. The functional O-mannose glycan on α-dystroglycan contains a phospho-Ribitol primed for matriglycan addition. Elife. 2016 Apr 29;5. pii: e14473.

[2]. Toivari MH, et al. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol. Appl Microbiol Biotechnol. 2010 Jan;85(3):731-9.

[相关活性小分子]

侧金盏花醇物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
494.5±40.0 °C at 760 mmHg

[ 熔点 ]:
101-104ºC

[ 分子式 ]:
C₅H₁₂O₅

[ 分子量 ]:
152.146

[ 闪点 ]:
261.9±21.9 °C

[ 精确质量 ]:
152.068466

[ PSA ]:
101.15000

[ LogP ]:
-3.77

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±2.9 mmHg at 25°C

[ 折射率 ]:
1.571

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

侧金盏花醇MSDS

详细MSDS(安全技术说明书)

侧金盏花醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VJ0800000

CHEMICAL NAME :: Ribitol

CAS REGISTRY NUMBER :: 488-81-3

BEILSTEIN REFERENCE NO. :: 1720524

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H12-O5

MOLECULAR WEIGHT :: 152.17

WISWESSER LINE NOTATION :: Q1YQYQYQ1Q -RIB

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 35,98,1936 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9704 No. of Facilities: 116 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 2181 (estimated) No. of Female Employees: 1615 (estimated)

侧金盏花醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
VJ0800000

侧金盏花醇合成路线

详细合成路线

侧金盏花醇上下游产品

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侧金盏花醇文献

Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography.

J. Chromatogr. A. 1361 , 265-76, (2014)

This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u...

Proteomic and metabolomic analysis of the carotenogenic yeast Xanthophyllomyces dendrorhous using different carbon sources.

BMC Genomics 16 , 289, (2015)

Astaxanthin is a potent antioxidant with increasing biotechnological interest. In Xanthophyllomyces dendrorhous, a natural source of this pigment, carotenogenesis is a complex process regulated throug...

Selective removal of phosphate for analysis of organic acids in complex samples.

J. Chromatogr. A. 1388 , 1-8, (2015)

Accurate quantitation of compounds in samples of biological origin is often hampered by matrix interferences one of which occurs in GC-MS analysis from the presence of highly abundant phosphate. Conse...

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