毛壳球菌素

毛壳球菌素用途

Chaetoglobosin A 是青霉 (Penicillium aquamarinium) 提取物中的活性成分,是细胞松弛素家族 (cytochalasan family) 的成员。 Chaetoglobosin A 优先诱导细胞凋亡 (apoptosis)。Chaetoglobosin A 靶向 CLL 细胞中的丝状肌动蛋白 (filamentous actin),从而诱导细胞周期停滞并抑制膜皱褶和细胞迁移。

毛壳球菌素名称

[ CAS 号 ]:
50335-03-0

[ 中文名 ]:
毛壳球菌素

[ 英文名 ]:
Chaetoglobosin A

[英文别名 ]:

chaetoglobosins
Chaetoglobosin A
CHAETOGLOBOSIN A
CHAETOGLOBOSIN
CHAETOGLOBOSINB
18-dimethyl-,(7s,13e,16s,17e,19r,21e)-ol-3-yl)-1
CHAETOGLOBOSINE
CHAETOGLOBOSINM
CHAETOGLOBOSINL

毛壳球菌素生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 其他

[ 靶点 ]

Filamentous actin[1]

[参考文献]

[1]. Knudsen PB, et al. Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia. 2014 Jun;28(6):1289-98.

毛壳球菌素物理化学性质

[ 密度 ]:
1.3 g/cm3

[ 沸点 ]:
789.7ºC at 760 mmHg

[ 分子式 ]:
C₃₂H₃₆N₂O₅

[ 分子量 ]:
528.63900

[ 闪点 ]:
431.4ºC

[ 精确质量 ]:
528.26200

[ PSA ]:
111.79000

[ LogP ]:
4.16120

[ 折射率 ]:
1.651

[ 储存条件 ]:
库房低温通风干燥,与食品原料分开存放

毛壳球菌素MSDS

详细MSDS(安全技术说明书)

毛壳球菌素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HA5305000

CHEMICAL NAME :: (13)Cytochalasa-13,17,21-triene-1,20,23-trione, 6,7-epoxy-19-hydroxy-10-(1H-indol-3-yl)- 16,18-dimethyl-, (7S,13E,16S,17E,19R,21E)-

CAS REGISTRY NUMBER :: 50335-03-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C32-H36-N2-O5

MOLECULAR WEIGHT :: 528.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JJEMAG Japanese Journal of Experimental Medicine. (Kinokuniya Book-Stores of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581 Webster St., San Francisco, CA 94115) V.7- 1928- Volume(issue)/page/year: 48,105,1978

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes Liver - other changes

REFERENCE :: JJEMAG Japanese Journal of Experimental Medicine. (Kinokuniya Book-Stores of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581 Webster St., San Francisco, CA 94115) V.7- 1928- Volume(issue)/page/year: 48,105,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JJEMAG Japanese Journal of Experimental Medicine. (Kinokuniya Book-Stores of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581 Webster St., San Francisco, CA 94115) V.7- 1928- Volume(issue)/page/year: 48,105,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6500 ug/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - chronic pulmonary edema

REFERENCE :: JJEMAG Japanese Journal of Experimental Medicine. (Kinokuniya Book-Stores of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581 Webster St., San Francisco, CA 94115) V.7- 1928- Volume(issue)/page/year: 48,105,1978 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 700 ug/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :: MAIKD3 Maikotokishin (Tokyo). Mycotoxin. (Maikotokishin Kenkyukai, c/o Tokyo Rika Daigaku Yakugakubu, 12 Funagawara-machi, Ichigaya, Shinjuku-ku, Tokyo 162, Japan) No.1- 1975- Volume(issue)/page/year: (10),17,1980

毛壳球菌素安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

毛壳球菌素文献

Exploiting the cytoskeletal filaments of neoplastic cells to potentiate a novel therapeutic approach.

Biochim. Biophys. Acta 1846(2) , 599-616, (2014)

Although cytoskeletal-directed agents have been a mainstay in chemotherapeutic protocols due to their ability to readily interfere with the rapid mitotic progression of neoplastic cells, they are all ...

Chaetoglobosin K induces apoptosis and G2 cell cycle arrest through p53-dependent pathway in cisplatin-resistant ovarian cancer cells.

Cancer Lett. 356(2 Pt B) , 418-33, (2015)

Adverse side effects and acquired resistance to conventional platinum based chemotherapy have become major impediments in ovarian cancer treatment, and drive the development of more selective anticanc...

Chaetoglobosin F, a small molecule compound, possesses immunomodulatory properties on bone marrow-derived dendritic cells via TLR9 signaling pathway.

Immunobiology 218(3) , 292-302, (2013)

Chaetoglobosin F (Cha F), a cytochalasan-based alkaloid, was obtained from the EtOAc extract of a solid culture of Chaetomium globosum IFB-E019. Dendritic cells (DCs), the most potent antigen presenti...

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