Pyrrolidine,1,1'-(2-butyne-1,4-diyl)bis-

名称

[ CAS 号 ]:
51-73-0

[ 英文名 ]:
Pyrrolidine,1,1'-(2-butyne-1,4-diyl)bis-

[英文别名 ]:

Tremorin
1,4-Dipyrrolidine-2-butyne
Tremorine
1,1'-but-2-yne-1,4-diyl-bis-pyrrolidine
1,4-dipyrrolidino-but-2-yne
1,4-Dipyrrolidino-2-butyne
Biofermin
1,4-Dipyrrolidino-but-2-in
1,4-Dipyrrolidino-2-butin
1,4-Dipyrrolidinyl-2-butyne

物理化学性质

[ 密度 ]:
1.014g/cm3

[ 沸点 ]:
285.6ºC at 760mmHg

[ 分子式 ]:
C₁₂H₂₀N₂

[ 分子量 ]:
192.30100

[ 闪点 ]:
118.4ºC

[ 精确质量 ]:
192.16300

[ PSA ]:
6.48000

[ LogP ]:
1.05720

[ 折射率 ]:
1.531

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY0175000

CHEMICAL NAME :: Pyrrolidine, 1,1'-(2-butynylene)di-

CAS REGISTRY NUMBER :: 51-73-0

BEILSTEIN REFERENCE NO. :: 0006119

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C12-H20-N2

MOLECULAR WEIGHT :: 192.34

WISWESSER LINE NOTATION :: T5NTJ A2UU2- AT5NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1727,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 58 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 56(3),83S,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 112 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#12070

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 135,447,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972

安全信息

[ 危险品运输编码 ]:
UN 2810

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933990090

合成路线

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海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%