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Roseoflavin

Roseoflavin用途

Roseoflavin 是一种天然色素,最初从 Streptomyces davawensis 中分离出来,是核黄素和黄素单核苷酸的抗代谢类似物,具有抗菌作用。

Roseoflavin名称

[ CAS 号 ]:
51093-55-1

[ 中文名 ]:
玫瑰黄色素

[ 英文名 ]:
Roseoflavin

[英文别名 ]:

Roseoflavine
Riboflavin,8-demethyl-8-(dimethylamino)
C18H23N5O6
8-Dimethylaminoriboflavin
8-demethyl-8-(dimethylamino)riboflavin
Roseoflavin

Roseoflavin生物活性

[ 描述 ]:

Roseoflavin 是一种天然色素,最初从 Streptomyces davawensis 中分离出来,是核黄素和黄素单核苷酸的抗代谢类似物,具有抗菌作用。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[体外研究]

玫瑰黄酮是黄素单核苷酸(FMN)和核黄素的化学类似物,具有抗菌活性,可直接与FMN核糖开关(Kd～100nm)适体结合,下调枯草芽孢杆菌FMN核糖开关lacZ报告基因的表达[1]。

[参考文献]

[1]. Lee ER, et al. Roseoflavin is a natural antibacterial compound that binds to FMN riboswitches and regulates gene expression. RNA Biol. 2009;6(2):187-194.

Roseoflavin物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 熔点 ]:
276-278ºC

[ 分子式 ]:
C₁₈H₂₃N₅O₆

[ 分子量 ]:
404.417

[ 精确质量 ]:
404.169586

[ PSA ]:
151.91000

[ LogP ]:
-0.55

[ 折射率 ]:
1.688

[ 储存条件 ]:
-20°C

Roseoflavin毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VJ1300000

CHEMICAL NAME :: Riboflavin, 8-demethyl-8-(dimethylamino)-

CAS REGISTRY NUMBER :: 51093-55-1

LAST UPDATED :: 199309

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H23-N5-O6

MOLECULAR WEIGHT :: 405.46

WISWESSER LINE NOTATION :: T C666 BN DNVMV INJ B1YQYQYQ1Q L1 MN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,277,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 27,88,1974