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磺胺索嘧啶

磺胺索嘧啶用途

Sulfisomidin 是一种磺胺类抗菌药物。

磺胺索嘧啶名称

[ CAS 号 ]:
515-64-0

[ 中文名 ]:
磺胺索嘧啶

[ 英文名 ]:
sulfisomidine

[中文别名 ]:

[英文别名 ]:

Solfisomidina
Sulfaisodimidinum
Sulfaisodimidine
Sulfisomidin
Sulfaisomidine
6-(Sulfanilamido)-2,4-dimethyl-1,3-diazine
sulfisomidine
Sulfadimetine
Sulfuisodimidine
Sulphasomidine

磺胺索嘧啶生物活性

[ 描述 ]:

Sulfisomidin 是一种磺胺类抗菌药物。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[体外研究]

磺胺异嘧啶(Sulfaisodimidine)是一种短效抗菌剂[1]。

[参考文献]

[1]. Bridges JW, et al. Species differences in the metabolism and excretion of sulphasomidine andsulphamethomidine. Biochem J. 1969 Jan;111(2):173-9.

[相关活性小分子]

磺胺索嘧啶物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
480.7±55.0 °C at 760 mmHg

[ 熔点 ]:
245ºC

[ 分子式 ]:
C₁₂H₁₄N₄O₂S

[ 分子量 ]:
278.330

[ 闪点 ]:
244.5±31.5 °C

[ 精确质量 ]:
278.083740

[ PSA ]:
106.35000

[ LogP ]:
-0.43

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.644

[ 储存条件 ]:
0-6°C

磺胺索嘧啶MSDS

磺胺索嘧啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WO9270000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(2,6-dimethyl-4-pyrimidinyl)-

CAS REGISTRY NUMBER :: 515-64-0

BEILSTEIN REFERENCE NO. :: 0261305

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C12-H14-N4-O2-S

MOLECULAR WEIGHT :: 278.36

WISWESSER LINE NOTATION :: T6N CNJ B1 D1 FMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6 gm/kg

SEX/DURATION :: female 9-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 13,7,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 2500 mg/kg

SEX/DURATION :: female 8-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: AKGIAO Akushcherstvo i Ginekologiya (Moscow). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1936- Volume(issue)/page/year: 43(12),10,1967

磺胺索嘧啶安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26;S36

[ 危险品运输编码 ]:
UN 3249

[ RTECS号 ]:
WO9270000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2935009090

磺胺索嘧啶合成路线

磺胺索嘧啶上下游产品

磺胺索嘧啶上游产品

磺胺索嘧啶下游产品

磺胺索嘧啶海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

磺胺索嘧啶文献

Fast determination of 22 sulfonamides from chicken breast muscle using core-shell nanoring amino-functionalized superparamagnetic molecularly imprinted polymer followed by liquid chromatography-tandem mass spectrometry.

J. Chromatogr. A. 1345 , 17-28, (2014)

A novel, simple and sensitive method was developed for the simultaneous determination of 22 sulfonamides (SAs) in chicken breast muscle by using the dispersive micro-solid-phase extraction (d-μ-SPE) p...

Multiresidue analysis of sulfonamides, quinolones, and tetracyclines in animal tissues by ultra-high performance liquid chromatography-tandem mass spectrometry.

Food Chem. 204 , 252-62, (2016)

A multiresidue method for the efficient identification and quantification of 38 compounds from 3 different classes of antibiotics (tetracyclines, sulfonamides, and quinolones) in animal tissues has be...

Coulometric determination of sulphisomidine, sulphamethoxydiazine and sulphamoxole.

J. Pharm. Biomed. Anal. 9(2) , 199-201, (1991)

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