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4,6-二氧代庚酸

4,6-二氧代庚酸用途

4,6-Dioxoheptanoic acid 是一种有效的血红素生物合成抑制剂。

4,6-二氧代庚酸名称

[ CAS 号 ]:
51568-18-4

[ 中文名 ]:
4,6-二氧代庚酸

[ 英文名 ]:
4,6-Dioxoheptanoic acid

[英文别名 ]:

4,6-Dioxoheptanoic acid
Succinylacetone
4,6-DIOXOHEPTANOIC ACID

4,6-二氧代庚酸生物活性

[ 描述 ]:

4,6-Dioxoheptanoic acid 是一种有效的血红素生物合成抑制剂。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 心血管疾病

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

检测4,6-二氧代庚酸(琥珀酰丙酮,SA)的能力a)抑制血红素途径的第二种酶,δ-氨基乙酰丙酸(ALA)脱水酶,b)降低血红素浓度,和c)抑制小鼠红白血病(MEL)细胞在培养中的细胞生长[1]。

[参考文献]

[1]. Ebert PS, et al. Succinylacetone, a potent inhibitor of heme biosynthesis: effect on cell growth, heme contentand delta-aminolevulinic acid dehydratase activity of malignant murine erythroleukemia cells. Biochem Biophys Res Commun. 1979 Jun 27;88(4):1382-90.

[相关活性小分子]

4,6-二氧代庚酸物理化学性质

[ 密度 ]:
1.189 g/cm3

[ 沸点 ]:
318.7ºC at 760 mmHg

[ 熔点 ]:
66-67ºC

[ 分子式 ]:
C₇H₁₀O₄

[ 分子量 ]:
158.15200

[ 闪点 ]:
160.8ºC

[ 精确质量 ]:
158.05800

[ PSA ]:
71.44000

[ LogP ]:
0.39940

[ 外观性状 ]:
粉末

[ 折射率 ]:
1.455

[ 储存条件 ]:
2-8°C

4,6-二氧代庚酸MSDS

4,6-二氧代庚酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2918300090

4,6-二氧代庚酸合成路线

4,6-二氧代庚酸上下游产品

4,6-二氧代庚酸上游产品

4,6-二氧代庚酸下游产品

4,6-二氧代庚酸海关

[ 海关编码 ]: 2918300090

[ 中文概述 ]:
2918300090 其他含醛基或酮基不含其他含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

4,6-二氧代庚酸文献

The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation.

Haematologica 100 , 720-9, (2015)

Feline leukemia virus subgroup C receptor 1 (Flvcr1) encodes two heme exporters: FLVCR1a, which localizes to the plasma membrane, and FLVCR1b, which localizes to mitochondria. Here, we investigated th...

Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis.

J. Immunol. 195 , 2763-73, (2015)

Pulmonary tuberculosis (TB) is characterized by oxidative stress and lung tissue destruction by matrix metalloproteinases (MMPs). The interplay between these distinct pathological processes and the im...

Single dose NTBC-treatment of hereditary tyrosinemia type I.

J. Inherit. Metab. Dis. 35(5) , 831-6, (2012)

NTBC (2-(2-nitro-4-trifluoromethylbenzoyl)-1,3cyclohexanedione) is the mainstay of treatment in tyrosinemia type 1 (HT 1). The current recommendation is to divide the total daily dose of NTBC into two...

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