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左旋环氧氯丙烷

左旋环氧氯丙烷用途

【用途一】
用于手性中间体及手性药物的合成
【用途二】
多种手性医药中间体。

左旋环氧氯丙烷名称

[ CAS 号 ]:
51594-55-9

[ 中文名 ]:
(R)-(−)-环氧氯丙烷

[ 英文名 ]:
(R)-(-)-Epichlorohydrin

[中文别名 ]:

[英文别名 ]:

EINECS 424-280-2
(2R)-(Chloromethyl)oxirane
(R)-Chloromethyloxirane
EPICHLOROHYDRIN, (-)-
(R)-3-Chloropropylene Oxide
(2R)-(-)-2-(Chloromethyl)oxirane
(2R)-(-)-3-Chloro-1,2-propenoxide
(R)-(-)-Epichlorohydrin
(R)-(−)-Epichlorohydrin
(-)-Epichlorohydrin

左旋环氧氯丙烷物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
116.1±0.0 °C at 760 mmHg

[ 熔点 ]:
-48ºC

[ 分子式 ]:
C₃H₅ClO

[ 分子量 ]:
92.524

[ 闪点 ]:
33.9±0.0 °C

[ 精确质量 ]:
92.002892

[ PSA ]:
12.53000

[ LogP ]:
0.45

[ 外观性状 ]:
无色至淡黄色液体

[ 蒸汽压 ]:
22.0±0.2 mmHg at 25°C

[ 折射率 ]:
1.444

[ 储存条件 ]:
2~8°C

[ 水溶解性 ]:
水溶性：可溶；混溶：乙醚,醇,苯

左旋环氧氯丙烷MSDS

左旋环氧氯丙烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RR0427000

CHEMICAL NAME :: Oxirane, (chloromethyl)-, (R)-

CAS REGISTRY NUMBER :: 51594-55-9

BEILSTEIN REFERENCE NO. :: 1420785

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C3-H5-Cl-O

MOLECULAR WEIGHT :: 92.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 298,197,1993

左旋环氧氯丙烷安全信息

[ 符号 ]:

GHS02, GHS05, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H301-H311-H314-H317-H331-H350

[ 警示性声明 ]:
P201-P261-P280-P301 + P310-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R10;R23/24/25;R34;R43;R45

[ 安全声明 (欧洲) ]:
S45-S53

[ 危险品运输编码 ]:
UN 2023

[ WGK德国 ]:
3

[ RTECS号 ]:
RR0427000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2910900090

左旋环氧氯丙烷合成路线

左旋环氧氯丙烷上下游产品

左旋环氧氯丙烷上游产品

左旋环氧氯丙烷下游产品

左旋环氧氯丙烷海关

[ 海关编码 ]: 2910900090

[ 中文概述 ]:
2910900090. 三节环环氧化物，环氧醇（酚，醚），包括其卤化，磺化，硝化或亚硝化的衍生物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

左旋环氧氯丙烷文献

Halogenated derivatives QSAR model using spectral moments to predict haloacetic acids (HAA) mutagenicity.

Bioorg. Med. Chem. 16 , 5720-32, (2008)

The risk of the presence of haloacetic acids in drinking water as chlorination by-products and the shortage of experimental mutagenicity data for most of them requires a research work. This paper desc...

The intramolecular asymmetric Pauson-Khand cyclization as a novel and general stereoselective route to benzindene prostacyclins: synthesis of UT-15 (treprostinil).

J. Org. Chem. 69 , 1890, (2004)

A general and novel solution to the synthesis of biologically important stable analogues of prostacyclin PGI(2), namely benzindene prostacyclins, has been achieved via the stereoselective intramolecul...

Strategy for the enantioselective synthesis of trans-2,4-disubstituted piperidines: application to the CCR3 antagonist IS811.

J. Org. Chem. 71 , 8975, (2006)

A strategy for the enantioselective synthesis of trans-2,4-disubstituted piperidines is proposed and applied to the preparation of IS811, a potent CCR3 antagonist. The C2 stereocenter is derived from ...

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