1,3-二氯丙醇

1,3-二氯丙醇用途

【用途一】
用于抗病毒药更昔洛韦的合成，用作醋酸纤维、乙基纤维的溶剂，也用于制造环氧树脂、离子交换树脂等
【用途二】
用作醋酸纤维、乙基纤维等的溶剂，也用于有机合成
【用途三】
用作乙酸纤维、乙基纤维的溶剂。也是环氧树脂、离子交换树脂、环氧氯丙烷的中间体。
【用途四】
用作乙酸纤维、乙基纤维的溶剂。也是环氧树脂、离子交换树脂、环氧氯丙烷的中间体

1,3-二氯丙醇名称

[ CAS 号 ]:
96-23-1

[ 中文名 ]:
1,3-二氯-2-丙醇

[ 英文名 ]:
1,3-Dichloro-2-propanol

[中文别名 ]:

[英文别名 ]:

1,3-dichloro-1,3-dideoxyglycerol
2-Propanol, 1,3-dichloro-
glycerol 1,3-dichlorohydrin
U 25,354
1,3-dichloro-2-hydroxypropane
EINECS 202-491-9
1,3-dichlorohydrin
DCP
gdch
1,3-DCP

1,3-二氯丙醇物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
174.3±0.0 °C at 760 mmHg

[ 熔点 ]:
-4 °C

[ 分子式 ]:
C₃H₆Cl₂O

[ 分子量 ]:
128.985

[ 闪点 ]:
85.6±0.0 °C

[ 精确质量 ]:
127.979568

[ PSA ]:
20.23000

[ LogP ]:
0.66

[ 外观性状 ]:
无色至淡黄色液体

[ 蒸汽压 ]:
0.4±0.7 mmHg at 25°C

[ 折射率 ]:
1.462

[ 储存条件 ]:
包装完整、轻装轻卸,库房通风、远离明火、高温、与氧化剂分开存放

[ 水溶解性 ]:
soluble. >=10 g/100 mL at 23 ºC

1,3-二氯丙醇MSDS

1,3-二氯丙醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UB1400000

CHEMICAL NAME :: 2-Propanol, 1,3-dichloro-

CAS REGISTRY NUMBER :: 96-23-1

BEILSTEIN REFERENCE NO. :: 1732063

LAST UPDATED :: 199801

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C3-H6-Cl2-O

MOLECULAR WEIGHT :: 128.99

WISWESSER LINE NOTATION :: G1YQ1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 125 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 800 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4550 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 250 umol/L

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9,401,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Carcinogen JAN 1993 OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5378 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 200 (estimated) No. of Female Employees: 6 (estimated)

1,3-二氯丙醇安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H312-H350

[ 警示性声明 ]:
P201-P280-P301 + P310-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R21;R25;R45

[ 安全声明 (欧洲) ]:
S53-S45-S36/37-S16

[ 危险品运输编码 ]:
UN 2750 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
UB1400000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29055910

1,3-二氯丙醇合成路线

1,3-二氯丙醇上下游产品

1,3-二氯丙醇上游产品

1,3-二氯丙醇下游产品

1,3-二氯丙醇制备

1.由氯丙烯与次氯酸反应而得。

2.由甘油在冰醋酸存在的情况下，与氯化氢反应而得。原料消耗定额：甘油796kg/t、氯化氢781.2kg/t、冰醋酸66.2kg/t。

精制方法：减压蒸馏精制。

3.制法：

于称量过的反应瓶中加入90%的甘油(2)500g（4.9mol），10g醋酸，装一根通气管深入至瓶底，油浴加热，控制油浴的温度100～110℃。通入干燥的氯化氢气体(由氯化铵与硫酸反应制备)。开始时氯化氢气体吸收很快，随着时间的延长，吸收逐渐减慢。当质量增加约440g时，停止通氯化氢气体。冷却后减压抽出氯化氢。慢慢加入固体碳酸钠，中和反应体系中的酸，直至呈弱碱性。可适当加入水以利于同碳酸钠的反应，约加水200mL。分出水层，而后减压蒸馏，收集68℃/1.65kPa以下的馏分(约110g)和68～75/1.65kPa的馏分(约385g)。将第一馏分中的水分出后重新蒸馏，收集68～75/1.65kPa的馏分，得约50g产品。将该馏分的产物重新蒸馏，收集70～73/1.65kPa的馏分，得1,3-二氯-2-丙醇^①(1)350g,收率55%。注：①也可由烯丙基氯与次氯酸反应来制备1,3-二氯-2-丙醇，反应式如下。[1]

1,3-二氯丙醇海关

[ 海关编码 ]: 2905590090

[ 中文概述 ]:
2905590090 其他无环醇的卤化、磺化等衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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