<生产厂家价格>

甲基丙二酸

甲基丙二酸用途

Methylmalonate 是癌症患者维生素 B-12 缺乏的指标。

甲基丙二酸名称

[ CAS 号 ]:
516-05-2

[ 中文名 ]:
甲基丙二酸

[ 英文名 ]:
Methylmalonic acid

[中文别名 ]:

[英文别名 ]:

Methylmalonic acid
Propanedioic acid, 2-methyl-
Methylpropanedioic acid
EINECS 208-219-5
2-Methylmalonic acid
methyl-Propanedioic acid
2-Methylpropanedioic acid
MFCD00002656
methyl-Malonic acid
2-Methyl1-malonic acid

甲基丙二酸生物活性

[ 描述 ]:

Methylmalonate 是癌症患者维生素 B-12 缺乏的指标。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 癌症

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

甲基丙二酸(甲基丙二酸; MMA)需要维生素B-12转化为琥珀酰-CoA,并与叶酸结合,使高半胱氨酸(HC)转化为甲硫氨酸。因此,与HC相比,甲基丙二酸酯显然更特异于维生素B-12缺乏[1]。

[参考文献]

[1]. Vashi P, et al. Methylmalonic Acid and Homocysteine as Indicators of Vitamin B-12 Deficiency in Cancer. PLoS One. 2016 Jan 25;11(1):e0147843.

[相关活性小分子]

甲基丙二酸物理化学性质

[ 密度 ]:
1.45

[ 沸点 ]:
334.4±25.0 °C at 760 mmHg

[ 熔点 ]:
129-136 ºC

[ 分子式 ]:
C₄H₆O₄

[ 分子量 ]:
118.088

[ 闪点 ]:
170.2±19.7 °C

[ 精确质量 ]:
118.026611

[ PSA ]:
74.60000

[ LogP ]:
-0.21

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.474

[ 储存条件 ]:
?20°C

[ 水溶解性 ]:
soluble

甲基丙二酸MSDS

甲基丙二酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OO1400000

CHEMICAL NAME :: Malonic acid, methyl-

CAS REGISTRY NUMBER :: 516-05-2

BEILSTEIN REFERENCE NO. :: 1756084

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H6-O4

MOLECULAR WEIGHT :: 118.10

WISWESSER LINE NOTATION :: QV1VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,222,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02314

甲基丙二酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
OO1400000

[ 海关编码 ]:
2917190090

甲基丙二酸合成路线

甲基丙二酸海关

[ 海关编码 ]: 2917190090

[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

甲基丙二酸文献

Physiology and pathophysiology of organic acids in cerebrospinal fluid.

J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

更多文献