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IP3K抑制剂

IP3K抑制剂用途

IP3K Inhibitor是 IP3K 的抑制剂，IC₅₀ 值为10.2 μM。

IP3K抑制剂名称

[ CAS 号 ]:
519178-28-0

[ 中文名 ]:
IP3K抑制剂

[ 英文名 ]:
TNP

[英文别名 ]:

N2-(m-Trifluorobenzyl) (N6-(p-nitrobenzyl)purine
Purine,5
IP3K Inhibitor
N2-(m-Trifluorobenzyl),N6-(p-nitrobenzyl)purine
Inositol-1,4,5-trisphosphate 3-Kinase Inhibitor

IP3K抑制剂生物活性

[ 描述 ]:

IP3K Inhibitor是 IP3K 的抑制剂,IC50 值为10.2 μM。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

[ 靶点 ]

IC50: 10.2 μM (IP3K)[1]

[体外研究]

IP3K抑制剂与IP3K的ATP结合位点结合,抑制常数Ki为4.3μM。 IP3K抑制剂是CDK1的显着较弱的抑制剂(IC50>100μM)。在用IP3K抑制剂处理后,细胞内钙水平以剂量依赖性方式增加超过1±2分钟,并且在20μM浓度的IP3K抑制剂中几乎完全不存在任何随后的ATP诱导的钙释放[1]。

[参考文献]

[1]. Chang YT, et al. Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem. 2002 Sep 2;3(9):897-901.

[相关活性小分子]

IP3K抑制剂物理化学性质

[ 分子式 ]:
C₂₀H₁₆F₃N₇O₂

[ 分子量 ]:
443.38200

[ 精确质量 ]:
443.13200

[ PSA ]:
127.57000

[ LogP ]:
4.52220

[ 储存条件 ]:
-20°C，密闭，干燥

IP3K抑制剂MSDS

详细MSDS(安全技术说明书)

IP3K抑制剂安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H319

[ 警示性声明 ]:
P264-P301 + P310-P305 + P351 + P338

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

IP3K抑制剂文献

Development of anti-HER2 fragment antibody conjugated to iron oxide nanoparticles for in vivo HER2-targeted photoacoustic tumor imaging.

Nanomedicine: Nanotechnology, Biology, and Medicine 11 , 2051-60, (2015)

Photoacoustic (PA) imaging is a promising imaging modality that provides biomedical information with high sensitivity and resolution. Iron oxide nanoparticles (IONPs) have been regarded as remarkable ...

Regulation of the Min Cell Division Inhibition Complex by the Rcs Phosphorelay in Proteus mirabilis.

J. Bacteriol. 197 , 2499-507, (2015)

A key regulator of swarming in Proteus mirabilis is the Rcs phosphorelay, which represses flhDC, encoding the master flagellar regulator FlhD4C2. Mutants in rcsB, the response regulator in the Rcs pho...

Facilitated monocyte-macrophage uptake and tissue distribution of superparmagnetic iron-oxide nanoparticles.

PLoS ONE 4 , e4343, (2009)

We posit that the same mononuclear phagocytes (MP) that serve as target cells and vehicles for a host of microbial infections can be used to improve diagnostics and drug delivery. We also theorize tha...

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