屈他雄酮丙酸酯

屈他雄酮丙酸酯用途

Dromostanolone propionate (Drostanolone propionate) 是一种具有抗乳腺癌活性的化合物。Dromostanolone propionate 能抑制肿瘤对雌二醇 -17ß 的摄取,但对正常乳腺组织的摄取没有明显影响。Dromostanolone propionate 植入颗粒能使动物的体重增加并抑制雌性动物发情。

屈他雄酮丙酸酯名称

[ CAS 号 ]:
521-12-0

[ 中文名 ]:
屈他雄酮丙酸酯

[ 英文名 ]:
Dromostanolone propionate

[中文别名 ]:

[英文别名 ]:

2a-Methyl-17b-(1-oxopropoxy)-5a-androstan-3-one
Masteril
Dromostanolone 17-propionate
MDHT
Dromostanolone propionate
Emdisterone
EINECS 208-303-1
Drostanolone propionate
Masterone
Permastril

屈他雄酮丙酸酯生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Takeuchi S, et al. Clinical experience with dromostanolone propionate (NSC-12198) in breast carcinoma. Saishin Igaku. 1967 May;22(5):1049-54.

[2]. N.Deshpande, et al. Accumulation of tritiated oestradiol by human breast tissue. Steroids, 1967 Sep;10(3), 219–232.

[3]. Brian H. Vickery . Dromostanolone propionate implant pellet useful for producing weight gains in animals and suppressing estrus in female animals. US3991750A.

屈他雄酮丙酸酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
445.9±45.0 °C at 760 mmHg

[ 熔点 ]:
114-120ºC

[ 分子式 ]:
C₂₃H₃₆O₃

[ 分子量 ]:
360.530

[ 闪点 ]:
190.5±28.8 °C

[ 精确质量 ]:
360.266449

[ PSA ]:
43.37000

[ LogP ]:
5.67

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.522

[ 储存条件 ]:
Controlled Substance, -20?C Freezer

屈他雄酮丙酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8067300

CHEMICAL NAME :: 5-alpha-Androstan-3-one, 17-beta-hydroxy-2-alpha-methyl-, propionate

CAS REGISTRY NUMBER :: 521-12-0

BEILSTEIN REFERENCE NO. :: 3161958

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H36-O3

MOLECULAR WEIGHT :: 360.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,534,1982

屈他雄酮丙酸酯安全信息

[ 危害码 (欧洲) ]:
Xi