地喹氯铵
地喹氯铵用途
地喹氯铵名称
[ CAS 号 ]:
522-51-0
[ 中文名 ]:
地喹氯铵
[ 英文名 ]:
Dequalinium Chloride
[中文别名 ]:
[英文别名 ]:
- DECA
- efisol
- dekamin
- evazol
- le chlorure de dequalinium
- dekadin
- EINECS 208-330-9
- BADQ-10
- dequadin
- eriosept
地喹氯铵生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
[相关活性小分子]
地喹氯铵物理化学性质
[ 熔点 ]:
≥300 °C(lit.)
[ 分子式 ]:
C30H40Cl2N4
[ 分子量 ]:
527.571
[ 精确质量 ]:
526.263000
[ PSA ]:
59.80000
[ LogP ]:
1.34060
[ 外观性状 ]:
粉末
[ 储存条件 ]:
2-8°C
地喹氯铵MSDS
地喹氯铵毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VA0700000
- CHEMICAL NAME :
- Quinaldinium, 1,1'-decamethylenebis(4-amino-, dichloride
- CAS REGISTRY NUMBER :
- 522-51-0
- LAST UPDATED :
- 199603
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C30-H40-N4.2Cl
- MOLECULAR WEIGHT :
- 527.64
- WISWESSER LINE NOTATION :
- T66 BKJ C1 EZ B10- BT66 BKJ C1 EZ &Q 2 &G 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18300 ug/kg
- TOXIC EFFECTS :
- Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 82,231,1993
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 70 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 8,110,1956
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1900 ug/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 8,110,1956 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg/15W-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 82,231,1993
地喹氯铵安全信息
[ 危害码 (欧洲) ]:
Xi:Irritant;
[ 风险声明 (欧洲) ]:
R36/37/38
[ 安全声明 (欧洲) ]:
S26-S36
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
VA0700000
[ 海关编码 ]:
2933499090
地喹氯铵海关
[ 海关编码 ]: 2933499090
[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
地喹氯铵文献
Curr. Probl. Dermatol. 40 , 36-47, (2011)
Vaginally applied antimicrobial agents are widely used in the vagina in women with lower genital tract infections. An 'antimicrobial' is a general term that refers to a group of drugs that are effecti...
Dequalinium induces cytotoxicity in human leukemia NB4 cells by downregulation of Raf/MEK/ERK and PI3K/Akt signaling pathways and potentiation of specific inhibitors of these pathways.Leuk. Res. 38(7) , 795-803, (2014)
Delocalized lipophilic cation dequalinium (DQA) selectively accumulates in mitochondria and displays anticancer activity in different malignancies. Our previous studies indicate a DQA-induced cytotoxi...
N-palmitoyl-ethanolamine (PEA) induces peripheral antinociceptive effect by ATP-sensitive K+-channel activation.J. Pharmacol. Sci. 118(2) , 156-60, (2012)
Although the antinociceptive effects of N-palmitoyl-ethanolamine (PEA) were first characterized nearly 50 years ago, the identity of the mechanism that mediates these actions has not been elucidated. ...
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联系人:徐乾明
产品详情:DequaliniumChloride
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产品详情:Dequalinium Chloride
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¥392.0/10mg
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联系人:夏言
产品详情:[Perfemiker]Dequalinium Chloride,99%
公司名:中山市迪欣化工有限公司
区域:中山市三角镇
价格:
¥120000.0/1kg
联系人:王洁
产品详情:地喹氯铵
公司名:湖北魏氏化学试剂股份有限公司
区域:武汉市洪山区
价格:
¥需询单/1kg
联系人:张栋
产品详情:地喹氯铵
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相关化合物
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标题:地喹氯铵_MSDS_用途_熔点_地喹氯铵CAS号【522-51-0】_化源网 地址:https://www.chemsrc.com/amp/cas/522-51-0_587443.html