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磺胺苯吡唑

磺胺苯吡唑用途

Sulfaphenazole是CYP2C9的特异性抑制剂, 抑制CYP2C9介导的亚油酸动脉粥样硬化和促炎症效应 (增加AP-1的氧化应激和激活), 用作抗菌剂。

磺胺苯吡唑名称

[ CAS 号 ]:
526-08-9

[ 中文名 ]:
磺胺苯吡唑

[ 英文名 ]:
Sulfaphenazole

[中文别名 ]:

磺胺苯基吡唑

[英文别名 ]:

MFCD00057226
EINECS 208-384-3
4-amino-N-(2-phenylpyrazol-3-yl)benzenesulfonamide
Sulfaphenazole

磺胺苯吡唑生物活性

[ 描述 ]:

Sulfaphenazole是CYP2C9的特异性抑制剂, 抑制CYP2C9介导的亚油酸动脉粥样硬化和促炎症效应 (增加AP-1的氧化应激和激活), 用作抗菌剂。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

磺胺苯吡唑物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
541.9±56.0 °C at 760 mmHg

[ 熔点 ]:
179-183ºC

[ 分子式 ]:
C₁₅H₁₄N₄O₂S

[ 分子量 ]:
314.362

[ 闪点 ]:
281.5±31.8 °C

[ 精确质量 ]:
314.083740

[ PSA ]:
98.39000

[ LogP ]:
1.52

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.684

[ 储存条件 ]:
库房通风低温干燥

磺胺苯吡唑MSDS

磺胺苯吡唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA9520000

CHEMICAL NAME :: Benzenesulfonamide, 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)-

CAS REGISTRY NUMBER :: 526-08-9

BEILSTEIN REFERENCE NO. :: 0308518

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C15-H14-N4-O2-S

MOLECULAR WEIGHT :: 314.39

WISWESSER LINE NOTATION :: T5NNJ BR& CMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 525 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3016 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MIMEAO Minerva Medica. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1909- Volume(issue)/page/year: 52,1789,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 440 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982

磺胺苯吡唑安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DA9520000

[ 海关编码 ]:
2935009090

磺胺苯吡唑合成路线

磺胺苯吡唑上下游产品

磺胺苯吡唑上游产品

磺胺苯吡唑下游产品

磺胺苯吡唑海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

磺胺苯吡唑文献

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Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins

Bioorg. Med. Chem. 17 , 896-904, (2009)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...

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