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木霉唑啉

木霉唑啉用途

Xylometazoline 是一种 α-肾上腺素能受体激动剂 (Ki=0.05-1.7 μM)。Xylometazoline 可收缩鼻腔血管,增加鼻腔气流。Xylometazoline 可用于鼻塞和流鼻涕的研究。

木霉唑啉名称

[ CAS 号 ]:
526-36-3

[ 中文名 ]:
赛洛唑啉

[ 英文名 ]:
xylometazoline

[中文别名 ]:

[英文别名 ]:

Novorin
Xylomethazoline
Otriven
Otrix
Xilometazolina
UNII-WPY40FTH8K
Otrivin
Xylometazoline
Xylometazolinum
Otrivine

木霉唑啉生物活性

[ 描述 ]:

Xylometazoline 是一种 α-肾上腺素能受体激动剂 (Ki=0.05-1.7 μM)。Xylometazoline 可收缩鼻腔血管,增加鼻腔气流。Xylometazoline 可用于鼻塞和流鼻涕的研究。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 炎症/免疫

[ 靶点 ]

Alpha-1A adrenergic receptor:0.05 μM (Ki)

Alpha-1B adrenergic receptor:0.30 μM (Ki)

Alpha-1D adrenergic receptor:0.15 μM (Ki)

Alpha-2A adrenergic receptor:0.88 μM (Ki)

Alpha-2B adrenergic receptor:1.7 μM (Ki)

Alpha-2C adrenergic receptor:0.19 μM (Ki)

[参考文献]

[1]. Ronald Eccles, et al. The nasal decongestant effect of xylometazoline in the common cold. Am J Rhinol. 2008 Sep-Oct;22(5):491-6.

[2]. Britta Haenisch, et al. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39.

木霉唑啉物理化学性质

[ 密度 ]:
1g/cm3

[ 沸点 ]:
394.2ºC at 760mmHg

[ 分子式 ]:
C₁₆H₂₄N₂

[ 分子量 ]:
244.38

[ 闪点 ]:
192.2ºC

[ 精确质量 ]:
244.19400

[ PSA ]:
24.39000

[ LogP ]:
2.90950

[ 储存条件 ]:
-20°C

木霉唑啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ2380000

CHEMICAL NAME :: 2-Imidazoline, 2-(4-tert-butyl-2,6-dimethylbenzyl)-

CAS REGISTRY NUMBER :: 526-36-3

BEILSTEIN REFERENCE NO. :: 0180524

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H24-N2

MOLECULAR WEIGHT :: 244.42

WISWESSER LINE NOTATION :: T5M CN BUTJ B1R B1 F1 DX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 215 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 29,729,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 46 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 29,729,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,971,1962

木霉唑啉安全信息

[ 海关编码 ]:
2933290090

木霉唑啉合成路线

详细合成路线

木霉唑啉海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%