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红霉素B

红霉素B名称

[ CAS 号 ]:
527-75-3

[ 中文名 ]:
红霉素B

[ 英文名 ]:
berythromycin

[英文别名 ]:

12-Deoxyerythromycin
berythromycinum
berythromycin
beritromicina
berythromycine
erythromycin B
berythromycinum [INN_la]
Erythromycin Impurity 2

红霉素B物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
807.6±65.0 °C at 760 mmHg

[ 熔点 ]:
168-170ºC (dec)

[ 分子式 ]:
C₃₇H₆₇NO₁₂

[ 分子量 ]:
717.927

[ 闪点 ]:
442.2±34.3 °C

[ 精确质量 ]:
717.466309

[ PSA ]:
173.68000

[ LogP ]:
3.12

[ 外观性状 ]:
白色至米白色固体

[ 蒸汽压 ]:
0.0±6.5 mmHg at 25°C

[ 折射率 ]:
1.527

[ 储存条件 ]:
20°C

红霉素B毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KF4700000

CHEMICAL NAME :: Erythromycin, 12-deoxy-

CAS REGISTRY NUMBER :: 527-75-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C37-H67-N-O12

MOLECULAR WEIGHT :: 718.05

WISWESSER LINE NOTATION :: T-14-VO GVTJ C2 D1 EQ F1 H1 JQ J1 L1 N1 KO- BT6OTJ CQ DN1&1 F1& MO- FT6OTJ B1 CQ DO1 D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 2,58,1980

红霉素B安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

红霉素B合成路线

详细合成路线

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红霉素B文献

A simple and rapid confirmatory assay for analyzing antibiotic residues of the macrolide class and lincomycin in bovine milk and yoghurt: hot water extraction followed by liquid chromatography/tandem mass spectrometry.

Rapid Commun. Mass Spectrom. 21(2) , 237-46, (2007)

A rapid and simple sample preparation procedure for determining residues of antibiotics of the class of macrolides and lincomycin in whole milk and yoghurt by liquid chromatography/tandem mass spectro...

Acid-catalyzed degradation of clarithromycin and erythromycin B: a comparative study using NMR spectroscopy.

J. Med. Chem. 43(3) , 467-74, (2000)

One of the major drawbacks in the use of the antibiotic erythromycin A is its extreme acid sensitivity, leading to degradation in the stomach following oral administration. The modern derivative clari...

An abiotic strategy for the enantioselective synthesis of erythromycin B.

Angew. Chem. Int. Ed. Engl. 42(28) , 3278-81, (2003)

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