527-75-3

• 常用中文名：红霉素B
• 常用英文名：berythromycin
• CAS号：527-75-3
• 分子式：C₃₇H₆₇NO₁₂
• 分子量：717.927
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-07-19 12:08:46
• 更新时间：2024-01-02 20:12:09

名称

• 中文名: 红霉素B
• 英文名: erythromycin B
• 英文别名: 12-Deoxyerythromycin; (3R,4S,5S,6R,7R,9R,11R,12S,13R,14R)-6-{[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione; berythromycinum; berythromycin; beritromicina; berythromycine; (3R,4S,6R,7R,9R,11R,12S,13R,14R)-6-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12-dihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione; erythromycin B; (3R,4S,5S,6R,7R,9R,11R,12S,13R,14R)-6-{[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (non-preferred name); berythromycinum [INN_la]; Erythromycin Impurity 2

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 807.6±65.0 °C at 760 mmHg
• 熔点: 168-170ºC (dec)
• 分子式: C₃₇H₆₇NO₁₂
• 分子量: 717.927
• 闪点: 442.2±34.3 °C
• 精确质量: 717.466309
• PSA: 173.68000
• LogP: 3.12
• 外观性状: 白色至米白色固体
• 蒸汽压: 0.0±6.5 mmHg at 25°C
• 折射率: 1.527
• 储存条件: 20°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KF4700000 CHEMICAL NAME : Erythromycin, 12-deoxy- CAS REGISTRY NUMBER : 527-75-3 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C37-H67-N-O12 MOLECULAR WEIGHT : 718.05 WISWESSER LINE NOTATION : T-14-VO GVTJ C2 D1 EQ F1 H1 JQ J1 L1 N1 KO- BT6OTJ CQ DN1&1 F1& MO- FT6OTJ B1 CQ DO1 D1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 2,58,1980

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H319
• 警示性声明: P305 + P351 + P338
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36
• 安全声明 (欧洲): 26
• 危险品运输编码: NONH for all modes of transport

合成路线

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