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3-氨基-7-甲基氨基吩噻嗪-5-氯化物

3-氨基-7-甲基氨基吩噻嗪-5-氯化物用途

Azure C是亚甲蓝(MB)或Azure B(AB)的顺序酶促氧化的产物。Azure C作为辣根过氧化物酶(HRP)的底物[1][2]。

3-氨基-7-甲基氨基吩噻嗪-5-氯化物名称

[ CAS 号 ]:
531-57-7

[ 中文名 ]:
天青C

[ 英文名 ]:
3-Amino-7-(methylamino)phenothiazin-5-ium chloride

[中文别名 ]:

[英文别名 ]:

MFCD00067677
N-Methylthionine
EINECS 208-512-8

3-氨基-7-甲基氨基吩噻嗪-5-氯化物生物活性

[ 描述 ]:

Azure C是亚甲蓝(MB)或Azure B(AB)的顺序酶促氧化的产物。Azure C作为辣根过氧化物酶(HRP)的底物[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Ferreira-Leitão V S, et al. Methylene blue and azure B oxidation by horseradish peroxidase: a comparative evaluation of class II and class III peroxidases. Applied Catalysis B: Environmental, 2003, 42(2): 213-221.

[2]. Lo Cascio F, et al. Azure C Targets and Modulates Toxic Tau Oligomers. ACS Chem Neurosci. 2018 Jun 20;9(6):1317-1326.

3-氨基-7-甲基氨基吩噻嗪-5-氯化物物理化学性质

[ 沸点 ]:
385.1ºC at 760 mmHg

[ 分子式 ]:
C₁₃H₁₂ClN₃S

[ 分子量 ]:
277.77

[ 闪点 ]:
186.7ºC

[ 精确质量 ]:
277.04400

[ PSA ]:
79.18000

[ LogP ]:
1.01270

[ 外观性状 ]:
固体

[ 储存条件 ]:
室温，避光

3-氨基-7-甲基氨基吩噻嗪-5-氯化物MSDS

3-氨基-7-甲基氨基吩噻嗪-5-氯化物毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SP5680000

CHEMICAL NAME :: Phenothiazin-5-ium, 3-amino-7-methylamino-, chloride

CAS REGISTRY NUMBER :: 531-57-7

LAST UPDATED :: 199504

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H12-N3-S.Cl

MOLECULAR WEIGHT :: 277.79

WISWESSER LINE NOTATION :: T C666 BN ISJ FZ MM1 &G &12/23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 umol/L/5H (Continuous)

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1536 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 36 (estimated) No. of Female Employees: 16 (estimated)

3-氨基-7-甲基氨基吩噻嗪-5-氯化物安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
SP5680000

[ 海关编码 ]:
2934300000

3-氨基-7-甲基氨基吩噻嗪-5-氯化物合成路线

3-氨基-7-甲基氨基吩噻嗪-5-氯化物海关

[ 海关编码 ]: 2934300000

[ 中文概述 ]:
2934300000. 含一个吩噻嗪环系的化合物(吩噻嗪环系不论是否氢化,化合物未经进一步稠合的 ). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3-氨基-7-甲基氨基吩噻嗪-5-氯化物文献

A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.

Bioorg. Med. Chem. Lett. 19 , 4952-7, (2009)

Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular oligome...

Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.

J. Biol. Chem. 282 , 10311-24, (2007)

Alzheimer disease is characterized by the abnormal aggregation of amyloid beta peptide into extracellular fibrillar deposits known as amyloid plaques. Soluble oligomers have been observed at early tim...

Note from the Biological Stain Commission: revision of azure B assay protocol.

Stain Technol. 63(1) , 65-9, (1988)

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