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PIT-1

PIT-1用途

PIT-1是一种选择性PIP3(磷脂酰肌醇3,4,5-三磷酸)拮抗剂。PIT-1通过抑制PIP3依赖的PI3K/Akt信号传导抑制癌细胞存活并诱导凋亡。PIT-1在体内具有抗肿瘤活性[1]。

PIT-1名称

[ CAS 号 ]:
53501-41-0

[ 英文名 ]:
PIT-1

[英文别名 ]:

PIT-1
Impentamine dihydrobromide

PIT-1生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K

[参考文献]

[1]. Miao B, et al. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31.

PIT-1物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 分子式 ]:
C₁₄H₁₀ClN₃O₄S

[ 分子量 ]:
351.765

[ 精确质量 ]:
351.008057

[ PSA ]:
139.27000

[ LogP ]:
4.28

[ 折射率 ]:
1.747

[ 储存条件 ]:
-20°C，密闭，干燥

PIT-1安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H400

[ 警示性声明 ]:
P273

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

PIT-1文献

Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.

Proc. Natl. Acad. Sci. U. S. A. 107(46) , 20126-31, (2010)

The PI3-kinase (PI3K) pathway regulates many cellular processes, especially cell metabolism, cell survival, and apoptosis. Phosphatidylinositol-3,4,5-trisphosphate (PIP3), the product of PI3K activity...

Inhibition of cell migration by PITENINs: the role of ARF6.

Oncogene 31(39) , 4317-32, (2012)

We have reported previously the development of small-molecule phosphatidylinositol-3,4,5-trisphosphate (PIP3) antagonists (PITs) that block pleckstrin homology (PH) domain interaction, including activ...

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