紫檀芪

紫檀芪用途

Pterostilbene 是从蓝莓和囊状紫檀中得到的芪类化合物[1],具有抗氧化、抗炎、抗癌、抗糖尿病和抗肥胖等功效[1][4]。Pterostilbene 抑制 ROS 的生成[3],能对抗多种自由基,例如 DPPH,ABTS,hydroxyl,superoxide 和 hydrogen peroxide 等[4]。

紫檀芪名称

[ CAS 号 ]:
537-42-8

[ 中文名 ]:
紫檀芪

[ 英文名 ]:
pterostilbene

[中文别名 ]:

[英文别名 ]:

4-(3,5-Dimethoxystyryl)phenol
4-[(E)-2-(3,5-Diméthoxyphényl)éthènyl]phénol
Phenol, 4-(2-(3,5-dimethoxyphenyl)ethenyl)-, (E)-
3,5-Dimethoxy-4'-hydroxy-trans-stilbene
3',5'-Dimethoxy-4-stilbenol
4-(2-(3,5-Dimethoxyphenyl)ethenyl)phenol
4-[(E)-2-(3,5-Dimethoxyphenyl)vinyl]phenol
(E)-4-(3,5-Dimethoxystyryl)phenol
Pterostilbene
4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol

紫檀芪生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

研究领域 >> 炎症/免疫

天然产物 >> 酚类

[体外研究]

紫檀芪(0,5,25,50,100,200和400μM)显示出对HeLa细胞生长的抑制活性,在24和48小时时IC50分别为101.2μM和65.9μM。 Ipterostilbene(0,25,100和200μM)也诱导HeLa细胞凋亡[2]。紫檀芪(0.05,0.1,0.15和0.2mM)以剂量依赖性方式对DPPH,ABTS,羟基,超氧化物,过氧化氢具有高抗氧化活性。紫檀芪降低脂质过氧化物和氢过氧化物,减少蛋白质羰基并恢复蛋白质巯基以响应TBHP和As-Fe2 +的损害。紫檀芪还抑制pBR322中的单链断裂[4]。

[体内研究]

紫檀芪(30 mg/kg每日,po为21天)抑制炎症动物模型中活性氧的产生[3]。

[参考文献]

[1]. McCormack D, et al. A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev. 2013;2013:575482.

[2]. Hong Bin W, et al. Pterostilbene (3',5'-dimethoxy-resveratrol) exerts potent antitumor effects in HeLa human cervical cancer cells via disruption of mitochondrial membrane potential, apoptosis induction and targeting m-TOR/PI3K/Akt signalling pathway. J BUON. 2018 Sep-Oct;23(5):1384-1389.

[3]. Perecko T, et al. The effects of pterostilbene on neutrophil activity in experimental model of arthritis. Biomed Res Int. 2013;2013:106041.

[4]. Acharya JD, et al. Protective effect of Pterostilbene against free radical mediated oxidative damage. BMC Complement Altern Med. 2013 Sep 26;13:238.

[相关活性小分子]

紫檀芪物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
420.5±35.0 °C at 760 mmHg

[ 熔点 ]:
89-92ºC

[ 分子式 ]:
C₁₆H₁₆O₃

[ 分子量 ]:
256.296

[ 闪点 ]:
208.1±25.9 °C

[ 精确质量 ]:
256.109955

[ PSA ]:
38.69000

[ LogP ]:
4.13

[ 外观性状 ]:
灰白色结晶粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.640

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
DMSO: >20mg/mL

紫檀芪MSDS

详细MSDS(安全技术说明书)

紫檀芪安全信息

[ 符号 ]:

GHS05, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H318-H411

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R41;R51/53

[ 安全声明 (欧洲) ]:
S26-S39-S61

[ 危险品运输编码 ]:
UN 3077

[ 包装等级 ]:
Ⅲ

[ 危险类别 ]:
9.0

[ 海关编码 ]:
2909500000

紫檀芪合成路线

详细合成路线

紫檀芪上下游产品

紫檀芪上游产品

紫檀芪下游产品

紫檀芪海关

[ 海关编码 ]: 2909500000

[ 中文概述 ]:
2909500000. 醚酚、醚醇酚及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

紫檀芪文献

Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377.

Free Radic. Biol. Med. 83 , 214-26, (2015)

High dietary fructose is an important causative factor in the development of metabolic syndrome-associated glomerular podocyte oxidative stress and injury. Here, we identified microRNA-377 (miR-377) a...

Anti-proliferative effect of pterostilbene on rat hepatoma cells in culture.

Cytotechnology 67 , 671-80, (2015)

Pterostilbene, a methoxylated analogue of resveratrol, is a natural compound primarily found in blueberries and several types of grapes. However, little is known about the effect of pterostilbene on t...

Involvement of the Nrf2 pathway in the regulation of pterostilbene-induced apoptosis in HeLa cells via ER stress.

J. Pharmacol. Sci. 126(3) , 216-29, (2014)

Among the various cancer cell lines, HeLa cells were found to be sensitive to pterostilbene (Pte), a compound that is enriched in small fruits such as grapes and berries. However, the mechanism involv...

更多文献

紫檀芪