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BML-210

BML-210用途

BML-210 是一类新颖的HDAC抑制剂，其IC50值为5 μM。

BML-210名称

[ CAS 号 ]:
537034-17-6

[ 中文名 ]:
BML-210

[ 英文名 ]:
BML-210

[英文别名 ]:

BML-210
N'-(2-aminophenyl)-N-phenyloctanediamide
N-(2-Aminophenyl)-N'-phenyloctanediamide
Octanediamide, N-(2-aminophenyl)-N-phenyl-

BML-210生物活性

[ 描述 ]:

BML-210 是一类新颖的HDAC抑制剂,其IC50值为5 μM。

[ 相关类别 ]:

研究领域 >> 癌症

[ 靶点 ]

HDAC4:MEF2

[参考文献]

[1]. Nimanthi Jayathilaka, et al. Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2. Nucleic Acids Res. 2012 Jul; 40(12): 5378–5388.

[2]. Veronika V. Borutinskaite, et al. Histone deacetylase inhibitor BML-210 induces growth inhibitionand apoptosis and regulates HDAC and DAPC complexexpression levels in cervical cancer cells. Mol Biol Rep (2012) 39:10179–10186

[3]. Veronika Borutinskaite, et al. The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming. Int J Mol Sci. 2015 Aug; 16(8): 18252–18269.

[相关活性小分子]

BML-210物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
632.5±40.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₂₅N₃O₂

[ 分子量 ]:
339.431

[ 闪点 ]:
336.3±27.3 °C

[ 精确质量 ]:
339.194672

[ PSA ]:
84.22000

[ LogP ]:
2.58

[ 外观性状 ]:
white solid

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.633

[ 储存条件 ]:
-20℃

BML-210安全信息

[ 危害声明 ]:
H413

[ 危险品运输编码 ]:
NONH for all modes of transport

BML-210文献

The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming.

Int. J. Mol. Sci. 16 , 18252-69, (2015)

Today, cancer is understood as an epigenetic as well as genetic disease. The main epigenetic hallmarks of the cancer cell are DNA methylation and histone modifications. Proteins such as histone deacet...

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