8-异戊烯基柚皮素

8-异戊烯基柚皮素用途

8-prenylnaringenin 是一种从啤酒花穗 (Humulus lupulus) 中分离到的异戊烯类黄酮,具有细胞毒性。8-prenylnaringenin 能通过诱导内源性、外源性通路介导的凋亡,对 HCT-116 结肠癌细胞产生抗增殖活性。8-Prenylnaringenin 能通过激活小鼠 Akt 磷酸化途径,促进其从静止诱导的停用性肌肉萎缩中恢复。

8-异戊烯基柚皮素名称

[ CAS 号 ]:
53846-50-7

[ 中文名 ]:
8-异戊烯基柚皮素

[ 英文名 ]:
8-Prenylnaringenin

[英文别名 ]:

8-Prenylnaringenin

8-异戊烯基柚皮素生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[参考文献]

[1]. Koosha S, et al. Antiproliferative and apoptotic activities of 8-prenylnaringenin against human colon cancer cells. Life Sci. 2019 Jul 3:116633.

[2]. Mukai R, et al. 8-Prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice. Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1022-R1031.

[3]. Stompor M, et al. In Vitro Effect of 8-Prenylnaringenin and Naringenin on Fibroblasts and Glioblastoma Cells-Cellular Accumulation and Cytotoxicity. Molecules. 2017 Jun 30;22(7).

8-异戊烯基柚皮素物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
597.6±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₂₀O₅

[ 分子量 ]:
340.370

[ 闪点 ]:
216.4±23.6 °C

[ 精确质量 ]:
340.131073

[ PSA ]:
86.99000

[ LogP ]:
5.28

[ 外观性状 ]:
黄色粉末

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.642

[ 储存条件 ]:
2-8°C

8-异戊烯基柚皮素安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

8-异戊烯基柚皮素文献

A comprehensive characterisation of beer polyphenols by high resolution mass spectrometry (LC-ESI-LTQ-Orbitrap-MS).

Food Chem. 169 , 336-43, (2014)

Beer is the second most consumed alcoholic beverage in Europe and shown by the European Prospective Investigation into Cancer and Nutrition cohort study to be the main food contributor to hydroxybenzo...

Involvement of a Hydrophobic Pocket and Helix 11 in Determining the Modes of Action of Prenylated Flavonoids and Isoflavonoids in the Human Estrogen Receptor.

ChemBioChem. 16 , 2668-77, (2016)

Six prenylated (iso)flavonoids were purified from a licorice root extract and subjected to competition experiments with six commercially available (iso)flavonoids. The agonistic and antagonistic activ...

Versatile antitumor potential of isoxanthohumol: Enhancement of paclitaxel activity in vivo.

Pharmacol. Res. 105 , 62-73, (2016)

Isoxanthohumol (IXN), a prenylated flavonoid from hops, exhibits diverse biological activities, e.g. antitumor, antiinflammatory, antioxidant and antiangiogenic. In this study, the effect of IXN is ev...

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