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安巴腙

安巴腙用途

Ambazone是一种口服活性膜活性抗肿瘤剂。Ambazone也显示出抗菌和较弱的抗病毒活性[1]。

安巴腙名称

[ CAS 号 ]:
539-21-9

[ 中文名 ]:
安巴腙

[ 英文名 ]:
Ambazone

[中文别名 ]:

[英文别名 ]:

Ambazona [inn-spanish]
Benzoqu
anginon
Faringosept
ambazon
promassol
primal
Ambazona
Inversal

安巴腙生物活性

[ 描述 ]:

Ambazone是一种口服活性膜活性抗肿瘤剂。Ambazone也显示出抗菌和较弱的抗病毒活性[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. G Löber, et al. Ambazone as a membrane active antitumor drug. Biophys Chem. 1990 Apr;35(2-3):287-300.

安巴腙物理化学性质

[ 密度 ]:
1.57g/cm3

[ 沸点 ]:
461.9ºC at 760mmHg

[ 熔点 ]:
195°C (rough estimate)

[ 分子式 ]:
C₈H₁₁N₇S

[ 分子量 ]:
237.28

[ 闪点 ]:
233.2ºC

[ 精确质量 ]:
237.08000

[ PSA ]:
156.76000

[ LogP ]:
1.42280

[ 外观性状 ]:
固体

[ 折射率 ]:
1.761

[ 储存条件 ]:
库房通风低温干燥

安巴腙毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF5550000

CHEMICAL NAME :: Guanidine, ((4-oxo-2,5-cyclohexadien-1-ylidene)amino)-, thiosemicarbazone

CAS REGISTRY NUMBER :: 539-21-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C8-H11-N7-S

MOLECULAR WEIGHT :: 237.32

WISWESSER LINE NOTATION :: SUYZMNU- AL6Y DYJ DUNMYZUM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 315 mg/kg/5D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 840 mg/kg/28D-I

TOXIC EFFECTS :: Gastrointestinal - other changes Endocrine - changes in thymus weight Blood - changes in bone marrow (not otherwise specified)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 625 mg/kg/5D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 10 gm/L

REFERENCE :: STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1966- Volume(issue)/page/year: 117,99,1987

安巴腙安全信息

[ 海关编码 ]:
2930909090

安巴腙合成路线

详细合成路线

安巴腙上下游产品

安巴腙上游产品

安巴腙下游产品

安巴腙海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

安巴腙