Surfen

Surfen用途

盐酸苏芬是一种有效的HS(硫酸乙酰肝素)拮抗剂。Surfen与糖胺聚糖结合。Surfen可中和普通肝素和低分子肝素的抗凝活性。Surfen影响肝素的硫酸化并抑制肝素裂解酶的降解。Surfen抑制FGF2结合和信号传导。Surfen抑制细胞附着和病毒感染[1]。

Surfen名称

[ CAS 号 ]:
5424-37-3

[ 英文名 ]:
Surfen

[英文别名 ]:

Aminoquincarbamide dihydrochloride
Aminoquinuride hydrochloride

Surfen生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 抗感染 >> HSV

研究领域 >> 感染

信号通路 >> 蛋白酪氨酸激酶 >> FGFR

信号通路 >> 蛋白酪氨酸激酶 >> VEGFR

[ 靶点 ]

FGFR2:5 μM (IC50)

HSV-1

[参考文献]

[1]. Schuksz M, et al. Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13075-80.

Surfen物理化学性质

[ 沸点 ]:
587.2ºC at 760 mmHg

[ 分子式 ]:
C₂₁H₂₂Cl₂N₆O

[ 分子量 ]:
445.34

[ 闪点 ]:
308.9ºC

[ 精确质量 ]:
408.14700

[ PSA ]:
118.95000

[ LogP ]:
6.31860

Surfen毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YS1950300

CHEMICAL NAME :: Urea, 1,3-bis(4-amino-2-methyl-6-quinolyl)-, dihydrochloride

CAS REGISTRY NUMBER :: 5424-37-3

LAST UPDATED :: 198308

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H20-N6-O.2Cl-H

MOLECULAR WEIGHT :: 445.39

WISWESSER LINE NOTATION :: T66 BNJ C1 EZ HMVM- HT66 BNJ C1 EZ &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 312 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 2,581,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16300 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 2,581,1952