鲨肝醇

鲨肝醇用途

【用途一】
用于白细胞减少症，预防白细胞减少，也可用于贫血症及小儿粒细胞缺乏症
【用途二】
该品是促进白细胞增生增生的常用药物之一。人的造血系统中含鲨肝醇较多，可能是体内的一种造血因子，具有增加粒细胞数量的作用，此外还有抗放射作用，能防治白细胞减少，临床用于因用抗肿瘤药及放射治疗而引起的白细胞减少，也可用于小儿粒细胞缺乏症。该品在治疗期间应每周检查白细胞数。

鲨肝醇名称

[ CAS 号 ]:
544-62-7

[ 中文名 ]:
鲨肝醇

[ 英文名 ]:
4-Oxadocosane-1,2-diol

[中文别名 ]:

[英文别名 ]:

4-Oxadocosane-1,2-diol
EINECS 208-874-7
DL-BATYL ALCOHOL
Batyl alcohol
C.1.Batylalcohol
1-o-octadecylglycerol
stearyl monoglyceride
3-octadecyloxy-1,2-propanediol
1-O-stearylglycerol monoether
BATILOL

鲨肝醇物理化学性质

[ 密度 ]:
0.914g/cm3

[ 沸点 ]:
471.1ºC at 760 mmHg

[ 熔点 ]:
71-73 °C(lit.)

[ 分子式 ]:
C₂₁H₄₄O₃

[ 分子量 ]:
344.57200

[ 闪点 ]:
238.7ºC

[ 精确质量 ]:
344.32900

[ PSA ]:
49.69000

[ LogP ]:
5.61770

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 折射率 ]:
1.464

[ 储存条件 ]:
-15°C

鲨肝醇MSDS

详细MSDS(安全技术说明书)

鲨肝醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TZ0960000

CHEMICAL NAME :: 1,2-Propanediol, 3-(octadecyloxy)-

CAS REGISTRY NUMBER :: 544-62-7

BEILSTEIN REFERENCE NO. :: 1725677

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H44-O3

MOLECULAR WEIGHT :: 344.65

WISWESSER LINE NOTATION :: Q1YQ1O18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3032 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle weakness

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,470,1948

鲨肝醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TZ0960000

[ 海关编码 ]:
2909499000

鲨肝醇上下游产品

鲨肝醇上游产品

鲨肝醇下游产品

鲨肝醇制备

将甘油与丙酮缩合生成1,2-异丙叉甘油醚，再与十八醇-对-甲苯磺酸酯进行醚化，得1,2-异丙叉-3-十八烷基甘油醚，最后经水解生成鲨肝醇。其他生产方法有从鲨鱼鱼肝油中分离等方法。鲨肝醇的双对硝基苯甲酸酯C35H50N2O9是淡黄色的针状结晶（甲醇中结晶），熔点65-66℃，63℃即开始软化。

鲨肝醇海关

[ 海关编码 ]: 2909499000

[ 中文概述 ]:
2909499000 其他醚醇及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

鲨肝醇文献

Quantitative lipidomic analysis of plasma and plasma lipoproteins using MALDI-TOF mass spectrometry.

Chem. Phys. Lipids 189 , 7-18, (2015)

Knowledge of the plasma lipid composition is essential to clarify the specific roles of different lipid species in various pathophysiological processes. In this study, we developed an analytical strat...

Homeostasis of phospholipids - The level of phosphatidylethanolamine tightly adapts to changes in ethanolamine plasmalogens.

Biochim. Biophys. Acta 1851(2) , 117-28, (2015)

Ethanolamine plasmalogens constitute a group of ether glycerophospholipids that, due to their unique biophysical and biochemical properties, are essential components of mammalian cellular membranes. T...

Glyceryl ether monooxygenase [EC 1.14.16.5]: stoichiometry and inhibition.

Adv. Exp. Med. Biol. 338 , 93-6, (1993)

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鲨肝醇