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喹碘方

喹碘方用途

Ferron(8-羟基-7-碘-5-喹啉磺酸)具有杀菌和抗真菌活性。Ferron可以防止皮肤和粘膜的细菌刺激和炎症[1]。

喹碘方名称

[ CAS 号 ]:
547-91-1

[ 中文名 ]:
高铁试剂

[ 英文名 ]:
Chiniofon

[中文别名 ]:

[英文别名 ]:

7-iodo-8-hydroxyquinoline-5-sulphonic acid
7-iodo-8-hydroxyquinoline-5-sulfonic acid
Chinoiodine
quiniophen
Chinoiodin
UNII-6E8Y02XFEI
meditrene
EINECS 208-938-4
8-hydroxy-7-iodoquinoline-5-sulfonic acid
ferron

喹碘方生物活性

[ 描述 ]:

Ferron(8-羟基-7-碘-5-喹啉磺酸)具有杀菌和抗真菌活性。Ferron可以防止皮肤和粘膜的细菌刺激和炎症[1]。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[参考文献]

[1]. Pippi B, et al. New insights into the mechanism of antifungal action of 8-hydroxyquinolines. Saudi Pharm J. 2019 Jan;27(1):41-48.

喹碘方物理化学性质

[ 密度 ]:
2.2±0.1 g/cm3

[ 熔点 ]:
269-270 °C (dec.)(lit.)

[ 分子式 ]:
C₉H₆INO₄S

[ 分子量 ]:
351.12

[ 精确质量 ]:
350.906219

[ PSA ]:
95.87000

[ LogP ]:
0.38

[ 外观性状 ]:
黄色-绿色粉末

[ 折射率 ]:
1.776

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable.

喹碘方MSDS

喹碘方毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC2800000

CHEMICAL NAME :: 5-Quinolinesulfonic acid, 8-hydroxy-7-iodo-

CAS REGISTRY NUMBER :: 547-91-1

BEILSTEIN REFERENCE NO. :: 0223832

LAST UPDATED :: 199706

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H6-I-N-O4-S

MOLECULAR WEIGHT :: 351.12

WISWESSER LINE NOTATION :: T66 BNJ GSWQ II JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 3,44,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 63,122,1938

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 63,122,1938

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 43,495,1954

喹碘方安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C: Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2585 8/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
VC2800000

[ 包装等级 ]:
III

[ 危险类别 ]:
8.0

[ 海关编码 ]:
2933499090

喹碘方合成路线

喹碘方制备

1.由8-羟基喹啉经发烟硫酸磺化、碘片及次氯酸钠碘化而得。

2.在搅拌下，将8-羟基喹啉慢慢加到发烟硫酸中，温度控制在15℃以下，加完后使温度保持在30℃以下5h，然后放置过夜：

之后，将水加到反应液中，使温度维持在60℃，当有结晶析出时，静置冷却，结晶完全后，过滤，结晶用水洗至无SO₄^2- 离子，甩干，再用乙醇洗涤后，于100℃下干燥。
将制得的8-羟基喹啉-5-磺酸加到20%的氢氧化钠溶液中，充分搅拌，冷却至20℃以下，再加入已溶于氢氧化钠稀溶液的碘片及次氯酸钠，进行反应：

搅拌0.5h后，慢慢加入盐酸至狆犎值为1～2，继续搅拌1h，静置、过滤。结晶先用水洗涤，甩干，再用乙醇洗涤，得产品高铁试剂。

喹碘方海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

喹碘方文献

Hydroxyl radicals cause fluctuation in intracellular ferrous ion levels upon light exposure during photoreceptor cell death.

Exp. Eye Res. 129 , 24-30, (2014)

Iron accumulation is a potential pathogenic event often seen in age-related macular degeneration (AMD) patients. In this study, we focused on the relationship between AMD pathology and concentrations ...

Proton-transfer compounds of 8-hydroxy-7-iodoquinoline-5-sulfonic acid (ferron) with 4-chloroaniline and 4-bromoaniline.

Acta Crystallogr. C 63(Pt 7) , o405-7, (2007)

The crystal structures of the proton-transfer compounds of ferron (8-hydroxy-7-iodoquinoline-5-sulfonic acid) with 4-chloroaniline and 4-bromoaniline, namely 4-chloroanilinium 8-hydroxy-7-iodoquinolin...

Polyaluminum chloride with high Al30 content as removal agent for arsenic-contaminated well water.

Water Res. 46(1) , 53-62, (2012)

Polyaluminum chloride (PACl) is a well-established coagulant in water treatment with high removal efficiency for arsenic. A high content of Al(30) nanoclusters in PACl improves the removal efficiency ...

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喹碘方