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3-羟基-2-氨基苯甲酸

3-羟基-2-氨基苯甲酸用途

3-Hydroxyanthranilic acid是犬尿氨酸途径中的色氨酸代谢物。

3-羟基-2-氨基苯甲酸名称

[ CAS 号 ]:
548-93-6

[ 中文名 ]:
3-羟基-2-氨基苯甲酸

[ 英文名 ]:
3-Hydroxyanthranilic acid

[中文别名 ]:

[英文别名 ]:

Acid, 3-Hydroxyanthranilic
MFCD00007700
3-hydroxy-Anthranilic acid
Anthranilic acid, 3-hydroxy-
3-Hydroxy-2-aminobenzoic acid
3-OH-anthranilic acid
EINECS 208-962-5
Benzoic acid, 2-amino-3-hydroxy-
2-Amino-3-hydroxybenzoic acid
3-Hydroxy-2-aminobenzoate

3-羟基-2-氨基苯甲酸生物活性

[ 描述 ]:

3-Hydroxyanthranilic acid是犬尿氨酸途径中的色氨酸代谢物。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Lee WS, et al. The tryptophan metabolite 3-hydroxyanthranilic acid suppresses T cell responses by inhibiting dendritic cell activation. Int Immunopharmacol. 2013 Nov;17(3):721-6.

[相关活性小分子]

3-羟基-2-氨基苯甲酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
356.9±37.0 °C at 760 mmHg

[ 熔点 ]:
240 °C (dec.)(lit.)

[ 分子式 ]:
C₇H₇NO₃

[ 分子量 ]:
153.135

[ 闪点 ]:
169.6±26.5 °C

[ 精确质量 ]:
153.042587

[ PSA ]:
83.55000

[ LogP ]:
1.05

[ 外观性状 ]:
固体;White to Brown powder to crystal

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.691

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
水溶性：微溶；可溶于：乙醚,氯仿,醇

3-羟基-2-氨基苯甲酸MSDS

3-羟基-2-氨基苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG2625000

CHEMICAL NAME :: Benzoic acid, 2-amino-3-hydroxy-

CAS REGISTRY NUMBER :: 548-93-6

BEILSTEIN REFERENCE NO. :: 0973356

LAST UPDATED :: 199612

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C7-H7-N-O3

MOLECULAR WEIGHT :: 153.15

WISWESSER LINE NOTATION :: ZR BQ FVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 185 mg/kg female 13-17 day(s) after conception

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Lungs, Thorax, or Respiration - bronchiogenic carcinoma

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 mg/kg/20W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors Endocrine - adrenal cortex tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8000 mg/kg/19W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2000 mg/kg/7W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2040 mg/kg/59W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 121 mg/kg/21D-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - bronchiogenic carcinoma Liver - tumors

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Primate - monkey Kidney

DOSE/DURATION :: 100 mg/L

REFERENCE :: TSITAQ Tsitologiya. Cytology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1959- Volume(issue)/page/year: 15,1505,1973 *** REVIEWS *** TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971

3-羟基-2-氨基苯甲酸安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332-H315-H319-H335-H351

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/21/22-36/37/38-40

[ 安全声明 (欧洲) ]:
S22-S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DG2625000

[ 海关编码 ]:
2922509090

3-羟基-2-氨基苯甲酸合成路线

3-羟基-2-氨基苯甲酸上下游产品

3-羟基-2-氨基苯甲酸上游产品

3-羟基-2-氨基苯甲酸下游产品

3-羟基-2-氨基苯甲酸海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

3-羟基-2-氨基苯甲酸文献

Increased conversion of tryptophan to nicotinamide in rats by dietary valproate.

Biosci. Biotechnol. Biochem. 77(2) , 295-300, (2013)

Valproic acid (VPA) is a short-chained, branched fatty acid that is widely used in humans as an anticonvulsant and mood stabilizer, and has been reported to increase the liver NAD concentration. We in...

Time-dependent effects of L-tryptophan administration on urinary excretion of L-tryptophan metabolites.

J. Nutr. Sci. Vitaminol. 60(4) , 255-60, (2014)

We have previously reported that dietary supplementation with up to 5.0 g/d of L-tryptophan (L-Trp) for 21 d has no adverse effects, judging from the levels of general blood variables, in healthy wome...

The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.

J. Nutr. 143(7) , 1046-51, (2013)

In mammals, nicotinamide (Nam) is biosynthesized from l-tryptophan (l-Trp). The enzymes involved in the initial step of the l-Trp→Nam pathway are l-Trp-2,3-dioxygenase (TDO) and indoleamine-2,3-dioxyg...

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