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二甲硝咪唑

二甲硝咪唑用途

Dimetridazole是一种硝基咪唑类药物, 对抗原虫感染。

二甲硝咪唑名称

[ CAS 号 ]:
551-92-8

[ 中文名 ]:
二甲硝咪唑

[ 英文名 ]:
1,2-Dimethyl-5-nitroimidazole

[中文别名 ]:

[英文别名 ]:

8595 R.P.
Dimetridazole
Unizole
EINECS 209-001-2
MFCD00047046
1,2-Dimethyl-5-nitroimidazole
Emtryl
1,2-Dimethyl-5-nitro-1H-imidazole
1H-Imidazole, 1,2-dimethyl-5-nitro-

二甲硝咪唑生物活性

[ 描述 ]:

Dimetridazole是一种硝基咪唑类药物, 对抗原虫感染。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

天然产物 >> 其他

[相关活性小分子]

二甲硝咪唑物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
313.7±15.0 °C at 760 mmHg

[ 熔点 ]:
177-182°C

[ 分子式 ]:
C₅H₇N₃O₂

[ 分子量 ]:
141.128

[ 闪点 ]:
143.5±20.4 °C

[ 精确质量 ]:
141.053833

[ LogP ]:
0.31

[ 外观性状 ]:
固体;White to Yellow to Green powder to crystal

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.599

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
水溶性：实际上不溶；易溶于：醇；极微溶：乙醚

二甲硝咪唑安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S22;S26;S36;S36/S37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NI5075000

二甲硝咪唑制备

以乙二醛为起始原料，与乙醛、氨环合，得2-甲基咪唑（C4H5N2，[693--98-1]）。然后硝化，得2-甲基-5-硝基咪唑（C4H6N3O2，[696-23-1]。最后以硫酸二甲酯甲基化即得甲硝咪唑。中间体2-甲基咪唑也可由乙二胺与乙腈环合得到2-甲基咪唑啉，然后加活性镍催化脱氢而得。

二甲硝咪唑文献

Determination of nitroimidazole residues in aquaculture tissue using ultra high performance liquid chromatography coupled to tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 960 , 105-15, (2014)

An UHPLC-MS/MS method was developed for the quantitative confirmatory analysis of residues of nitroimidazole drugs (dimetridazole, ipronidazole, metronidazole, ornidazole and ronidazole) and their cor...

Validation of a streamlined multiclass, multiresidue method for determination of veterinary drug residues in bovine muscle by liquid chromatography-tandem mass spectrometry.

Anal. Bioanal. Chem 407 , 4423-35, (2015)

Multiclass, multiresidue methods are becoming increasingly popular in regulatory monitoring programs due to their increased analytical scope and laboratory efficiency. In this work, we report the deve...

Development of a rapid method for the determination and confirmation of nitroimidazoles in six matrices by fast liquid chromatography-tandem mass spectrometry.

J. Pharm. Biomed. Anal. 64-65 , 40-8, (2012)

A rapid liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed to identify and to quantify nitroimidazoles, metronidazole (MNZ), ronidazole (RNZ) and dimetridazole (DMZ) and t...

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二甲硝咪唑

二甲硝咪唑用途

二甲硝咪唑名称

二甲硝咪唑生物活性

二甲硝咪唑物理化学性质

二甲硝咪唑安全信息

二甲硝咪唑制备

二甲硝咪唑文献

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