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五肽胃泌素

五肽胃泌素用途

pentagastrin是合成的多肽,能够在不经肠道情况上引起胃泌激素,并且引起唾液的分泌和合成蛋白质。

五肽胃泌素名称

[ CAS 号 ]:
5534-95-2

[ 中文名 ]:
五肽胃泌素

[ 英文名 ]:
Pentagastrin

[中文别名 ]:

五肽胃必素

[英文别名 ]:

pentagastrine
Pentagastrin
petogasrin
GRP
Gastrodiagnost
ay6608
EINECS 226-889-7
Peptavlon
petavlon
MFCD00076515

五肽胃泌素生物活性

[ 描述 ]:

pentagastrin是合成的多肽,能够在不经肠道情况上引起胃泌激素,并且引起唾液的分泌和合成蛋白质。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

[参考文献]

[1]. Loy F et al. Ultrastructural evidence of a secretory role for melatonin in the human parotid gland.J Physiol Pharmacol, 2015 Dec, 66(6):847-53.

[2]. Abdel-Salam O et al. Gastric acid inhibitory and gastric protective effects of Cannabis and cannabinoids. Asian Pac J Trop Med, 2016 May, 9(5):413-9.

[3]. Czekaj R et al. Role of curcumin in protection of gastric mucosa against stress-induced gastric mucosal damage. Involvement of hypoacidity, vasoactive mediators and sensory neuropeptides. J Physiol Pharmacol, 2016 Apr, 67(2):261-75.

[相关活性小分子]

五肽胃泌素物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
1196.6±65.0 °C at 760 mmHg

[ 熔点 ]:
229-230° (dec)

[ 分子式 ]:
C₃₇H₄₉N₇O₉S

[ 分子量 ]:
767.891

[ 闪点 ]:
677.5±34.3 °C

[ 精确质量 ]:
767.331238

[ PSA ]:
276.21000

[ LogP ]:
3.03

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.604

[ 储存条件 ]:
-20°C

五肽胃泌素MSDS

详细MSDS(安全技术说明书)

五肽胃泌素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY2970000

CHEMICAL NAME :: Alaninamide, N-carboxy-beta-alanyl-L-tryptophyl-L-methionyl-L-aspa rtylphenyl-, N-tert-butyl ester, L-

CAS REGISTRY NUMBER :: 5534-95-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C37-H49-N7-O9-S

MOLECULAR WEIGHT :: 767.99

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 5 ug/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - interstitial nephritis

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 289,470,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 38,612,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,766,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,776,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,766,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,766,1982

五肽胃泌素安全信息

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
61-36/38-20/21

[ 安全声明 (欧洲) ]:
S53-S45-S36/37/39-S22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
AY2970000

五肽胃泌素上下游产品

五肽胃泌素上游产品

五肽胃泌素下游产品

五肽胃泌素制备

以叔丁氧羰基-β-丙氨酸、色氨酸、甲硫氨酸、天冬氨酸、苯丙酰胺为原料，用保护剂保护其侧链后，依次用缩合剂将其缩合，然后除去保护剂精制而得。

五肽胃泌素文献

Vacuolar-type H+-ATPase-mediated proton transport in the rat parietal cell.

Pflugers Arch. 463(3) , 419-27, (2012)

The vacuolar-type H-ATPase (V-ATPase) plays an important role in the active acidification of intracellular organelles. In certain specialized cells, such as the renal intercalated cell, apical V-ATPas...

Functional and histologic assessment of rat gastric mucosa after chronic treatment with sulphurous thermal water.

Pharmacology 85(3) , 146-52, (2010)

The effect of a chronic (4 weeks) administration of sulphurous thermal water on gastric acid secretion and mucosal defense was investigated in rats. Animals were randomized to receive daily intake of ...

Failure of pentagastrin-stimulated calcitonin testing in early manifestation of familial medullary thyroid cancer.

Wien. Klin. Wochenschr. 124(19-20) , 723-4, (2012)

This case report describes three generations of a family with familial medullary thyroid cancer (RET gene mutation L790F). One of the three siblings-all of them carrier of the respective mutation-exhi...

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