3-硝基苯酚

3-硝基苯酚用途

【用途一】
用作分析试剂，也用于有机合成
【用途二】
用作医药、染料中间体
【用途三】
用于有机合成。该品还用作指示剂，pH6.8（无色）-8.6（黄色）。
【用途四】
有机合成用于制造染料等原料，用作分析试剂。用做酸碱指示剂，pH6.8-8.6(无色-黄色)。
【用途五】
有机合成用于制造染料等原料，用作分析试剂。用做酸碱指示剂，pH6.8-8.6(无色-黄色)。用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。

3-硝基苯酚名称

[ CAS 号 ]:
554-84-7

[ 中文名 ]:
间硝基苯酚

[ 英文名 ]:
3-Nitrophenol

[中文别名 ]:

[英文别名 ]:

m-Nitrophenol
m-Nitrophenol [UN1663] [Poison]
3-Hydroxynitrobenzene
Phenol,m-nitro
m-Nitrofenol [Czech]
3-nitro-phenol
EINECS 209-073-5
Phenol,3-nitro
m-Nitrofenol
MFCD00007240

3-硝基苯酚物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
277.6±0.0 °C at 760 mmHg

[ 熔点 ]:
89-95 °C

[ 分子式 ]:
C₆H₅NO₃

[ 分子量 ]:
139.109

[ 闪点 ]:
126.9±11.1 °C

[ 精确质量 ]:
139.026947

[ PSA ]:
66.05000

[ LogP ]:
1.93

[ 外观性状 ]:
黄色晶体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.612

[ 储存条件 ]:
库房通风低温干燥,与氧化剂,食品添加剂分开存放

[ 水溶解性 ]:
13.5 g/L (25 ºC)

3-硝基苯酚MSDS

详细MSDS(安全技术说明书)

3-硝基苯酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SM1925000

CHEMICAL NAME :: Phenol, m-nitro-

CAS REGISTRY NUMBER :: 554-84-7

LAST UPDATED :: 199710

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C6-H5-N-O3

MOLECULAR WEIGHT :: 139.12

WISWESSER LINE NOTATION :: WNR CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 328 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - coma

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1070 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 83 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - coma

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - muscle weakness Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 543 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 500 ug/disc

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 170,11,1986 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 47,75,1978

3-硝基苯酚安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H315-H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22;R33;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37-S45-S36/37/39-S22

[ 危险品运输编码 ]:
UN 1663 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
SM1925000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2908999090

3-硝基苯酚合成路线

详细合成路线

3-硝基苯酚上下游产品

3-硝基苯酚上游产品

3-硝基苯酚下游产品

3-硝基苯酚制备

由间硝基苯胺经重氮化；水解而得。将间硝基苯在搅拌下慢慢加入稀硫酸中，降温至0℃以下。在搅拌下慢慢加入亚硝酸钠水溶液，并保持温度在15℃以下，重氮化完成后反应液应为深棕色透明液体。再将重氮盐在搅拌下慢慢加入125℃的热稀硫酸中，加完后保温1-2h。放冷，将结晶滤出，用水洗至pH=3-4，滤干，减压蒸馏即得成品。

3-硝基苯酚海关

[ 海关编码 ]: 2908999090

[ 中文概述 ]:
2908999090 其他酚及酚醇的卤化等衍生物（包括其磺化、硝化或亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

3-硝基苯酚文献

cIEF for rapid pKa determination of small molecules: a proof of concept.

Eur. J. Pharm. Sci. 63 , 14-21, (2014)

A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) w...

Effect of nitro substituent on electrochemical oxidation of phenols at boron-doped diamond anodes.

Chemosphere 78(9) , 1093-9, (2010)

In order to investigate nitro-substitutent's effect on degradation of phenols at boron-doped diamond (BDD) anodes, cyclic voltammetries of three nitrophenol isomers: 2-nitrophenol (2NP), 3-nitrophenol...

Adsorption analysis of nitrophenol isomers on silver nanostructures by surface-enhanced spectroscopy.

J. Colloid. Interface Sci. 342(2) , 311-9, (2010)

SEIRA, SERS, TPD and DFT were used to study 4-nitrophenol (4NP), 3-nitrophenol (3NP) and 2-nitrophenol (2NP) adsorption on nanoscale silver films/powder. SERS and DFT demonstrated that 4NP adsorbed as...

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